1H-INDOLE-5-CARBOXAMIDE, 97%
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1H-INDOLE-5-CARBOXAMIDE, 97%
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CAS No:
1670-87-7
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Formula:
C9H8N2O
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Chemical Name:
1H-INDOLE-5-CARBOXAMIDE, 97%
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Synonyms:
1H-INDOLE-5-CARBOXAMIDE, 97%;SD-169;1H-Indole-5-carboxamide(9CI);5-(AMinocarbonyl)-1H-indole;5-CarbaMoylindole;p38 MAP Kinase Inhibitor VII, SD-169;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem
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CAS No:
1H-INDOLE-5-CARBOXAMIDE, 97% Basic Attributes
160.17
160.17
DTXSID50566323
Off-White to Light Purple
Characteristics
0.87 (LogP)
1.328±0.06 g/cm3(Predicted)
159-163 °C
457.6±18.0 °C(Predicted)
water: 1mg/mLDMSO: 10mg/mL
16.25±0.30(Predicted)
Sealed in dry,2-8°C
Safety Information
WGK 3
Xn
26
22-36/37/38
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1H-INDOLE-5-CARBOXAMIDE, 97% Use and Manufacturing
SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.
1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.
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