LOXOPROFEN SODIUM SALT
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LOXOPROFEN SODIUM SALT
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CAS No:
226721-96-6
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Formula:
C15H21NaO5
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Chemical Name:
LOXOPROFEN SODIUM SALT
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Synonyms:
LOXOPROFEN SODIUM SALT;Loxoprofen SodiuM Salt Dihydrate;LoxoprofenSodiumSaltDihydrate>;2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid Sodium Salt;Loxoprofen Impurity 72
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CAS No:
Description
Loxoprofen sodium hydrate is a hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an antipyretic. It contains a loxoprofen sodium.
LOXOPROFEN SODIUM SALT Basic Attributes
304.31401
304.12866805
Z2DR42L11Y
White to Almost white
2918.30.3000
Safety Information
III
6.1
CY1678845
UN 2811 6.1/PG III
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory.
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
156-S
LOXOPROFEN SODIUM SALT Use and Manufacturing
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4].
Drug Function and Efficacy
Non-steroidal anti-inflammatory drug (NSAID) for pain relief and inflammation reduction
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