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Fluxametamide

Fluxametamide structure

CAS No:
928783-29-3
Formula:
C20H16Cl2F3N3O3
Chemical Name:
Fluxametamide
Synonyms:
4-[5-(3,5-Dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methylbenzamide;FLUXAMETAMIDE;Benzamide, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[(methoxyamino)methylene]-2-methyl-;Fluxametamide-002;inhibit,Inhibitor,γ-Aminobutyric acid Receptor,GABA Receptor,Fluxametamide,Gamma-aminobutyric acid Receptor;Fluxametamide(mixture of isomers);4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-N-((methoxyamino)methylene)-2-methylbenzamide;Fluorofop
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-[(methoxyamino)methylidene]-2-methylbenzamide is a benzamide obtained by formal condensation of the carboxy group of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid with the amino group of N-methoxymethanimidamide. It is a member of benzamides, an isoxazoline, a dichlorobenzene, a member of formamidines, an organofluorine compound and an ether.

Fluxametamide is a novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels, acts as an antagonist of GABA- and glutamate-gated chloride channels(IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls).

Fluxametamide Basic Attributes

Molecular Weight：

474.26

Exact Mass：

473.0520813

EC Number：

813-746-4

Color/Form：

White to off-white

Characteristics

Density：

1.43±0.1 g/cm3(Predicted)

PKA：

11.29±0.46(Predicted)

Critical Temperature & Pressure：

Store at -20°C

Safety Information

GHS Classification：

|Warning|H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 90 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fluxametamide Use and Manufacturing

Fluxametamide is a novel insecticide belongs to a class of compounds called isoxazolines, which are potent inhibitors of γ-aminobutyric acid (GABA)-, glutamate-, and glycine-gated chloride channels in insects. However, this pesticidal mode of action (MOA) does not seem to be operative in mammals as neurotoxicity was not found in either the acute or subchronic neurotoxicity studies at the limit dose.

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