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4-Methylumbelliferyl-beta-D-glucuronide

4-Methylumbelliferyl-beta-D-glucuronide structure

CAS No:
6160-80-1
Formula:
C16H16O9
Chemical Name:
4-Methylumbelliferyl-beta-D-glucuronide
Synonyms:
4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-YL, BETA-D-GLUCO-PYRANOSIDURONIC ACID;4-METHYLUMBELLIFERYL B-D-GLUCURONIDE;4-METHYLUMBELLIFERYL-BETA-D-GLUCURONIC ACID;4-METHYLUMBELLIFERYL-BETA-D-GLUCURONIDE;MUG;MUGLCU;4-Methylumbelliferyl-b-D-glucuronide hydrate;4-methylumberiferryl-beta-D-glucuronide trihydrate
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Crystalline

4-methylumbelliferone beta-D-glucuronide is a beta-D-glucosiduronic acid having a 4-methylumbelliferyl substituent at the anomeric position. A hyaluronan synthesis inhibitor, it is anti-tumourigenic for various malignant tumours. It has a role as a chromogenic compound, an antineoplastic agent and a hyaluronan synthesis inhibitor. It is a member of coumarins, a monosaccharide derivative and a beta-D-glucosiduronic acid. It derives from a 4-methylumbelliferone. It is a conjugate acid of a 4-methylumbelliferone beta-D-glucuronide(1-).

4-Methylumbelliferyl-beta-D-glucuronide is a fluorescent substrate of β-glucuronidase. Once cleaved, 4-Methylumbelliferyl-beta-D-glucuronide yields blue fluorescence seen under UV light which is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively. It is ideal for working with Escherichia coli and plant molecular studies.

ChEBI: A beta-D-glucosiduronic acid having a 4-methylumbelliferyl substituent at the anomeric position.

4-Methylumbelliferyl-beta-D-glucuronide Basic Attributes

Molecular Weight：

352.3

Exact Mass：

352.29

EC Number：

228-186-0

TSCA：

TSCA listed

Color/Form：

White

HScode：

29329990

Characteristics

PSA：

146.66000

XLogP3：

-0.63

Density：

1.632±0.06 g/cm3(Predicted)

Melting Point：

102 °C

Boiling Point：

683.1±55.0 °C(Predicted)

Flash Point：

255.0±25.0 °C

Refractive Index：

1.664

Water Solubility：

slightly soluble

PKA：

2.76±0.70(Predicted)

Critical Temperature & Pressure：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Xi,Xn

safety instructions：

24/25-36/37

Marks：

Xi: Irritant;

Hazard Statements：

22-40

Drug Information

MeSH：

Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)

Metabolism/Metabolites：

4-Methylumbelliferone O-glucuronide is a known human metabolite of 4-Methylumbelliferone.

MeSH Entry Terms：

4-methylumbelliferyl glucuronide

4-Methylumbelliferyl-beta-D-glucuronide Use and Manufacturing

Uses

4-Methylumbelliferyl-beta-D-glucuronide is a substrate for glucuronidase. Also used as a test for coliform bacteria in water. Fluorescence: max. Abs. 316nm; max. Em. 375nm; e x 10-3: 12 Substrate for ?-D-glucuronidase assay. MUG is widely used as component of selective microbial culture media.

4-Methylumbelliferyl β-D-glucuronide dihydrate is a useful building block and a fluorophore.

Manufacturing Info：

.beta.-D-Glucopyranosiduronic acid, 4-methyl-2-oxo-2H-1-benzopyran-7-yl: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:352.29
XLogP3:-0.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:3
Exact Mass:352.07943208
Monoisotopic Mass:352.07943208
Topological Polar Surface Area:143
Heavy Atom Count:25
Complexity:574
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 4-Methylumbelliferyl-beta-D-glucuronide

Hangzhou Royalchem Co.,LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Pharmaceutical intermediates

4-Methylumbelliferyl-beta-D-glucuronide RC01672

Unit Price: $1 /KG EXW

CAS No.: 6160-80-1

Grade: Food Grade

Content: 99%

Inquiry
Wuhan Oner Biotech Co.,Ltd. Contact Supplier

CN
6 YRS

Business licensed

Distributor Supplier of Nutrition supplement material,Pharmaceutical raw material,Chemical raw material

4-Methylumbelliferyl-β-D-glucuronide dihydrate

Unit Price: $9.9-11.88 /KG FOB

CAS No.: 6160-80-1

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

MUG 99% white powder kanbei

CAS No.: 6160-80-1

Grade: Industrial Grade

Content: 99%

Inquiry

Latest News on 4-Methylumbelliferyl-beta-D-glucuronide

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Guide of 4-Methylumbelliferyl-beta-D-glucuronide

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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4-Methylumbelliferyl-beta-D-glucuronide

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