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Meclofenamate sodium

Meclofenamate sodium structure

CAS No:
6385-02-0
Formula:
C14H11Cl2NO2.Na
Chemical Name:
Meclofenamate sodium
Synonyms:
Benzoic acid,2-[(2,6-dichloro-3-methylphenyl)amino]-,sodium salt (1:1);Anthranilic acid,N-(2,6-dichloro-m-tolyl)-,monosodium salt;Benzoic acid,2-[(2,6-dichloro-3-methylphenyl)amino]-,monosodium salt;Sodium meclophenamate;Sodium meclofenamate;Sodium N-(2,6-dichloro-m-tolyl)anthranilate;N-(2,6-Dichloro-m-tolyl)anthranilic acid sodium salt;Meclomen;CI 583;Meclofenamate sodium;Meclofenamic acid sodium salt
Categories:
Active Pharmaceutical Ingredients > Antipyretic Analgesics

Description

Meclofenamic acid sodium is a nonsteroidal anti-inflammatory drug (NSAID) approved for use in arthritis (osteo and rheumatoid), analgesia (mild to moderate pain), dysmenorrhea, and heavy menstrual blood loss (menorrhagia). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor[1][2][3].

Sodium meclofenamate (anhydrous) is an organic sodium salt. It contains a meclofenamic acid(1-).|A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis.

Meclofenamate sodium Basic Attributes

Molecular Weight：

318.13

Exact Mass：

335.009186

EC Number：

228-983-3

UNII：

9MMQ0YER4E

DSSTox ID：

DTXSID8045567

HScode：

2922499990

Characteristics

PSA：

52.2

Melting Point：

287-291 °C

Boiling Point：

399.4°C at 760 mmHg

Flash Point：

195.3ºC

Water Solubility：

soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol

Collision Cross Section：

157 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

CB2975500

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

MeSH Entry Terms：

Benzoic acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, monosodium salt, monohydrate

Meclofenamate sodium Use and Manufacturing

Uses

antiinflammatory, antipyretic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:318.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:316.9986282
Monoisotopic Mass:316.9986282
Topological Polar Surface Area:52.2
Heavy Atom Count:20
Complexity:332
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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CAS No.: 6385-02-0

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6385-02-0 sodium;2-(2,6-dichloro-3-methylanilino)benzoate

CAS No.: 6385-02-0

Grade: Industrial Grade

Content: 95%

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