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2-Chloro-3-pyridinol

2-Chloro-3-pyridinol structure

CAS No:
6636-78-8
Formula:
C5H4ClNO
Chemical Name:
2-Chloro-3-pyridinol
Synonyms:
3-Pyridinol,2-chloro-;2-Chloro-3-pyridinol;2-Chloro-3-hydroxypyridine;3-Hydroxy-2-chloropyridine;NSC 18469
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

light beige powder

2-Chloro-3-pyridinol Basic Attributes

Molecular Weight：

129.54

Exact Mass：

129.54

BRN：

2216

EC Number：

229-635-3

UNII：

VY212Q0S3J

NSC Number：

18469

DSSTox ID：

DTXSID3022243

HScode：

2933399090

Characteristics

PSA：

33.1

XLogP3：

1.1

Appearance：

Light beige Powder

Density：

1.4±0.1 g/cm3

Melting Point：

165 °C

Boiling Point：

316.2°C at 760 mmHg

Flash Point：

145.0±22.3 °C

Refractive Index：

1.584

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38-20/21/22

safety instructions：

26-37/39-24/25-36

RTECS Number：

UU7707000

Marks：

Xi,Xn

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-chloro-3-hydroxypyridine

2-Chloro-3-pyridinol Use and Manufacturing

Methods of Manufacturing

General procedure: Toa solution of aryl triflate 1a-k (0.3 mmol) in distilledtoluene (5 mL) was added Cs2CO3(3 eq.). The suspension was heated at 80 °C (oilbath temp) during 15h. The crude mixture was quenched withethyl acetate (~5 mL) and a saturatedaqueous solution of ammonium chloride (~10 mL).The aqueous layer was extracted with ethyl acetate (2x10 mL). Organic layerswere then combined, dried over MgSO4 and concentratedunder reduced pressure to afford the corresponding phenol 2a-k that was purified byflash chromatography over silica gel.

Uses

Used as pharmaceutical intermediate

Computed Properties

Molecular Weight:129.54
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:128.9981414
Monoisotopic Mass:128.9981414
Topological Polar Surface Area:33.1
Heavy Atom Count:8
Complexity:78.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-Chloro-3-pyridinol

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

2-Chloro-3-hydroxypyridine

CAS No.: 6636-78-8

Content: 99.00%

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

2-chlorpyridin-3-ol cas6636-78-8

CAS No.: 6636-78-8

Grade: Pharmaceutical grade

Content: 99%

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