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(±)-Tolperisone

(±)-Tolperisone structure

CAS No:
728-88-1
Formula:
C16H23NO
Chemical Name:
(±)-Tolperisone
Synonyms:
1-Propanone,2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-;Propiophenone,2,4′-dimethyl-3-piperidino-;2-Methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone;2,4′-Dimethyl-3-piperidinopropiophenone;Mydeton;Tolperisone;Mideton;(±)-Tolperisone;dl-Tolperisone;Mydetone;NSC 107321;112537-33-4
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone is an aromatic ketone.|Tolperisone is an oral, centrally acting muscle relaxant. Its precise mechanism is not completely understood, though it blocks sodium and calcium channels. It possesses a high affinity for nervous system tissue, reaching highest concentrations in brain stem, spinal cord and peripheral nerves. Based on existing clinical data, Tolperisone is not sedating and does not interact with alcohol.|A centrally acting muscle relaxant that has been used for the symptomatic treatment of spasticity and muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1211)

(±)-Tolperisone Basic Attributes

Molecular Weight：

245.36

Exact Mass：

245.36

EC Number：

211-976-4

NSC Number：

107321

DSSTox ID：

DTXSID8023686|DTXSID20197148

ATC Code：

M - Musculo-skeletal system

Characteristics

PSA：

20.3

XLogP3：

3.23760

Density：

1.004g/cm3

Melting Point：

176-177 °C

Boiling Point：

373.9ºC at 760 mmHg

Flash Point：

134.4ºC

Refractive Index：

1.526

Safety Information

Precautionary statement(s)：

P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P322, P330, P337+P313, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P322, P330, P337+P313, P363, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Investigated for use/treatment in neurologic disorders, spinal cord injuries, muscle spasm, back pain, and multiple sclerosis.

MeSH：

A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358) (See all compounds classified as Muscle Relaxants, Central.)

MeSH Entry Terms：

Hydrochloride, Tolperisone

(±)-Tolperisone Use and Manufacturing

Central muscle relaxants and vasodilators.

Computed Properties

Molecular Weight:245.36
XLogP3:3.4
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:245.177964357
Monoisotopic Mass:245.177964357
Topological Polar Surface Area:20.3
Heavy Atom Count:18
Complexity:262
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (±)-Tolperisone

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Trader Supplier of vitamin

Tolperisone/Midocalm Powder

Unit Price: $8-9 /MT FOB

CAS No.: 728-88-1

Grade: Pharmaceutical Grade

Content: 99%

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