 Home > Encyclopedia > DBU

DBU

DBU structure

CAS No:
6674-22-2
Formula:
C9H16N2
Chemical Name:
DBU
Synonyms:
1,8-DIAZABICYCLO(5,4,0)UNDECENE-7;1,8-DIAZEBICYCLO[5.4.0]UNDEC-7-ENE;Pyrimido[1,2-a]azep;1,8-Diazabicyclo[5.4.]undec-7-ene;1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 25GR;1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 500GR;1,8-Diazabicyclo[5.4.0]undec-7-ene, 98% 5GR;1,8-Diazabicyclo[5.4.0]undec-7-ene,2,3,4,6,7,8,9,10-Octahydropyrimidol[1,2-a]azepine, DBU
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

Colorless to yellow liquid

Liquid

DBU is a bicyclic amidine base. It is non-nucleophilic, sterically hindered, tertiary amine base in organic chemistry. It is reported to be superior to amine catalyst in Baylis-Hillman reaction.It promotes the methylation reaction of phenols, indoles and benzimidazoles with dimethyl carbonate under mild conditions.

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency.Click herefor more information.

Fractionally distil DBU under vacuum. Also purify it by chromatography on Kieselgel and eluting with CHCl3/EtOH/25% aqueous NH3 (15:5:2) and checking by IR and MS. [Oediger et al. Chem Ber 99 2012 1962, Angew Chem, Int Ed Engl 6 76 1967, Guggisberg et al. Helv Chim Acta 61 1057 1978, Beilstein 23/5 V 271.]

DBU Basic Attributes

Molecular Weight：

152.24

Exact Mass：

152.24

BRN：

508906

EC Number：

229-713-7

UNII：

H1ILJ6IBUX

NSC Number：

111184

TSCA：

TSCA listed

DSSTox ID：

DTXSID2049424

Color/Form：

Clear colorless to light yellow

HScode：

29339930

Characteristics

PSA：

15.6

XLogP3：

1.4

Appearance：

Clear colorless to light yellow Liquid

Density：

1.019 g/mL at 20 °C(lit.)

Melting Point：

-70 °C

Boiling Point：

80-83 °C0.6 mm Hg(lit.)

Flash Point：

>230 °F

Refractive Index：

n20/D1.523

Water Solubility：

soluble

Storage Conditions：

Store at R.T.

Vapor Pressure：

5.3 mm Hg ( 37.7 °C)

Toxicity：

LD50 orally in Rabbit: 215 - 681 mg/kg

Flammability characteristics：

Non flammable

Odor：

Unpleasant

PH：

12.8 (10g/l, H2O, 20℃)

PKA：

13.28±0.20(Predicted)

Autoignition Temperature：

260 °C

Critical Temperature & Pressure：

Store below +30°C.

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 3267 8/PG 2

wgk germany：

hazard class code：

C,F

safety instructions：

26-36/37/39-45-61-27-16

Marks：

C,F

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides.

Precautionary statement(s)：

P260, P264, P270, P273, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, P501

Hazard Statements：

22-34-52/53-35-40-37-19-11-67

RIDADR：

UN 3267 8/PG 2

GHS Classification：

|Danger|H290 (10.1%): May be corrosive to metals [Warning Corrosive to Metals]|P234, P260, P264, P270, P273, P280, P301+P310, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P390, P404, P405, and P501|Aggregated GHS information provided by 653 companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

1,8-DBU

DBU Use and Manufacturing

Uses

Used in the manufacture of cephalosporin semi-synthetic antibiotic drugs, also used in the preparation of deacidification agents, rust inhibitors, advanced corrosion inhibitors, etc.

Intermediates

DBU may be used:as catalyst for carboxylic acid esterification with dimethyl carbonatein the synthesis of duocarmycin and CC-1065 analogsas catalyst in aza-Michael addition and Knovenegal condensation reactionas base for dehalogenation of halogenated Diels-Alder adducts and the resulting activated 2,4-dienones were subjected to regio- and stereo-directed Michael additions, using Yamamoto′s reagent (CH3Cu · BF3)in a new synthesis of the ABCD ring system of CamptothecinDBU may be used as an catalyst for the dissolution and activation of cellulose by a reversible reaction of its hydroxyl groups with carbon dioxide. This dissolved cellulose system can be derivatized to form cellulose mixed esters.Used in a new synthesis of the ABCD ring system of Camptothecin.

DBU is used in organic synthesis as a catalyst, a complexing ligand, and a non-nucleophilic base. It is used as a protecting agent for the synthesis of cephalosporin and as a catalyst for polyurethane.

Production

100,000 - 500,000 lb

Manufacturing Info：

All other basic organic chemical manufacturing|Pyrimido[1,2-a]azepine, 2,3,4,6,7,8,9,10-octahydro-: ACTIVE

Computed Properties

Molecular Weight:152.24
XLogP3:1.4
Hydrogen Bond Acceptor Count:1
Exact Mass:152.131348519
Monoisotopic Mass:152.131348519
Topological Polar Surface Area:15.6
Heavy Atom Count:11
Complexity:163
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of DBU

Dingwang Technology (Wuhan) Co., Ltd. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of API,nutrition supplements,plant extract,peptide,HCG

DBU, 1,8-Diazabicyclo[5,4,0]undec-7-ene (DBU) 98% colorless or light yellow liquid 6674-22-2 Senwayer

CAS No.: 6674-22-2

Grade: Pharmaceutical Grade

Content: 98%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

1,8-Diazabicyclo[5.4.0]undec-7-ene

CAS No.: 6674-22-2

Content: 99.00%

Inquiry
HANGZHOU HAILAN CHEMICAL CO.,LTD Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of intermediates ,fine chemical,food additives

1,8-DIAZABICYCLO[5,4,0]-7-UNDECENE HAILAN

CAS No.: 6674-22-2

Inquiry
Shanghai Lonwin Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of CHEMICALS,REAGENTS

High quality 1,8-Diazabicyclo[5.4.0]undec-7-ene CAS NO.6674-22-2

CAS No.: 6674-22-2

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
Shandong Sinwo Material Technology CO.,LTD Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of catalyst,Rubber auxiliary,cosmetic

SW-DBU

CAS No.: 6674-22-2

Grade: Chemical Grade

Content: 98%

Inquiry