Rhynchophylline
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Rhynchophylline
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CAS No:
76-66-4
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Formula:
C22H28N2O4
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Chemical Name:
Rhynchophylline
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Synonyms:
Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid,6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester,(αE,1′R,6′R,7′S,8′aS)-;Rhyncophylline;Corynoxan-16-carboxylic acid,16,17-didehydro-17-methoxy-2-oxo-,methyl ester,(7β,16E,20α)-;Mitrinermine;Rhynchophylline;Rhynchophyllin;Mitrinermin;Spiro[3H-indole-3,1′(5′H)-indolizine]-7′-acetic acid,6′-ethyl-1,2,2′,3′,6′,7′,8′,8′a-octahydro-α-(methoxymethylene)-2-oxo-,methyl ester,[1′R-[1′α,6′β,7′α(E),8′aβ]]-;NSC 21731;(-)-Rhynchophylline
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CAS No:
Description
Rhyncholphylline, an alkaloid isolated from Uncaria, shows potent inhibition of lipopolysaccharide (LPS)-induced NO production in rat primary microglial cells.IC50 value:Target:In vitro: Rhyncholphylline effectively suppresses release of proinflammatory cytokines in LPS-activated microglial cells and the underling molecular mechanism for the inhibition of microglial activation; Attenuated LPS-induced production of proinflammatory cytokines such as TNF-α and IL-1β as well as NO in mouse N
Characteristics
67.87000
3.31
Red brown or white fine powder
1.2±0.1 g/cm3
216 °C
560.8±50.0 °C at 760 mmHg
293.0±30.1 °C
1.596
0-10°C
D13 -14.7° (c = 2.5 in chloroform)
Computed Properties
Molecular Weight:384.5
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:384.20490738
Monoisotopic Mass:384.20490738
Topological Polar Surface Area:67.9
Heavy Atom Count:28
Complexity:663
Undefined Atom Stereocenter Count:4
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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