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Sodium fusidate

Sodium fusidate structure

CAS No:
751-94-0
Formula:
C31H48O6.Na
Chemical Name:
Sodium fusidate
Synonyms:
29-Nordammara-17(20),24-dien-21-oic acid,16-(acetyloxy)-3,11-dihydroxy-,sodium salt (1:1),(3α,4α,8α,9β,11α,13α,14β,16β,17Z)-;29-Nor-8α,9β,13α,14β-dammara-17(20),24-dien-21-oic acid,3α,11α,16β-trihydroxy-,16-acetate,monosodium salt,(Z)-;29-Nordammara-17(20),24-dien-21-oic acid,16-(acetyloxy)-3,11-dihydroxy-,monosodium salt,(3α,4α,8α,9β,11α,13α,14β,16β,17Z)-;SQ 16360;Fucidine;Fusidate sodium;Fucidin;Fusidin;Sodium fusidate;Sodium fusidin;Fusidic acid sodium salt;Fucidina;ZN 6-Na;Sodium fucidate;1110-01-6;1394-43-0;20291-17-2
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Fusidic acid sodium salt is a bacteriostatic antibiotic.

Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.|An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.

Sodium fusidate Basic Attributes

Molecular Weight：

538.69

Exact Mass：

538.327026

EC Number：

212-030-3

UNII：

J7P3696BCQ

DSSTox ID：

DTXSID9045552

NCI Thesaurus Code：

C65792

HScode：

29419000

Characteristics

PSA：

107

XLogP3：

4.33140

Appearance：

while crystalline power

Boiling Point：

635.6ºC at 760 mmHg

Flash Point：

197.6ºC

Water Solubility：

soluble in water

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice (g/kg): 0.2 i.v. (Godtfredsen, Nature 1962)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

26-36

RTECS Number：

LV5775000

Marks：

Xn,Xi

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (49.04%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P340, P312, P330, P403+P233, P405, and P501|Aggregated GHS information provided by 104 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

MeSH Entry Terms：

Acid, Fusidic

Sodium fusidate Use and Manufacturing

Sodium fusidate is the more water soluble sodium salt of fusidic acid, a steroidal metabolite of Fusidum coccineum which is a potent Gram positive antibiotic. Fusidic acid inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA. Fusidic acid also suppresses NO lysis of pancreatic islet cells.

Computed Properties

Molecular Weight:538.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:538.32703350
Monoisotopic Mass:538.32703350
Topological Polar Surface Area:107
Heavy Atom Count:38
Complexity:1000
Defined Atom Stereocenter Count:10
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It produces bactericidal effects by inhibiting bacterial protein synthesis and has a strong antibacterial effect on a series of Gram-positive bacteria. Staphylococci (including strains resistant to penicillin, methicillin and other antibiotics) are highly sensitive to this product. There is no cross-resistance and cross-allergy with other antibacterial drugs used in clinical practice, and it can be used to treat patients who are contraindicated to other antibiotics. It can be used in combination with a variety of anti-staphylococcal drugs to reduce drug resistance and obtain additive or synergistic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sodium Fusidate for Injection
Ingredients	The main ingredient of this product is sodium fusidate.
Indication	There are occasional reports that this product can increase the anticoagulant effect of coumarin drugs.
Specifications	0.125g, prepared with 10ml sterile buffer solution
Manufacturer	Chengdu Tiantai Mountain Pharmaceutical Co., Ltd.

Sodium Fusidate
Manufacturer	Sichuan Qingmu Pharmaceutical Co., Ltd.

Sodium Fusidate
Manufacturer	Haisco Pharmaceutical(Meishan) Co., Ltd.

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Registered Holders

Joyang Laboratories

United States
Active
Iqvia RDS (SHANGHAI) Co., Ltd.

China
Active
China Chinopharma Ltd

China
Active

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