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Perhexiline maleate

Perhexiline maleate structure

CAS No:
6724-53-4
Formula:
C19H35N.C4H4O4
Chemical Name:
Perhexiline maleate
Synonyms:
Piperidine,2-(2,2-dicyclohexylethyl)-,(2Z)-2-butenedioate (1:1);Piperidine,2-(2,2-dicyclohexylethyl)-,maleate (1:1);Piperidine,2-(2,2-dicyclohexylethyl)-,(Z)-2-butenedioate (1:1);Piperidine,2-(2,2-dicyclohexylethyl)-,maleate;2-(2,2-Dicyclohexylethyl)piperidine maleate;Perhexiline maleate;Pexid;Perhexilene maleate;103516-74-1
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Perhexiline maleate is a potent carnitine palmitoyltransferase 1 (CPT 1) inhibitor with IC50s of 77 and 148 μM for rat heart and liver CPT 1, respectively.

Perhexiline maleate Basic Attributes

Molecular Weight：

393.56

Exact Mass：

393.28800

EC Number：

229-775-5

UNII：

9GN57XTP25|84LEC42PQ8

NSC Number：

758409

DSSTox ID：

DTXSID1021114

HScode：

2933399090

Characteristics

PSA：

86.63000

XLogP3：

5.33600

Appearance：

white to tan

Melting Point：

188.5-191 °C

Boiling Point：

574.1ºC at 760 mmHg

Flash Point：

301ºC

Water Solubility：

DMSO: ≥5mg/mL

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Toxicity：

LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri)

Collision Cross Section：

179.8 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

TM7068000

Drug Information

MeSH Entry Terms：

perhexiline maleate

Perhexiline maleate Use and Manufacturing

Vasodilator, used in treatments for angina.

Computed Properties

Molecular Weight:393.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:393.28790873
Monoisotopic Mass:393.28790873
Topological Polar Surface Area:86.6
Heavy Atom Count:28
Complexity:364
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is a calcium antagonist that inhibits the influx of Ca2+, can relax vascular smooth muscle, significantly dilate coronary arteries, increase coronary blood flow, and has a good effect on angina pectoris. It can slow down the heart rate, reduce the load on the left ventricle, and thus reduce myocardial oxygen consumption. It has a good effect in treating angina pectoris. It is also effective for ventricular arrhythmias, but has a poor effect on supraventricular arrhythmias; this product often works for patients who are ineffective with other antiarrhythmic drugs.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Perhexiline Maleate Tablets
Specifications	50mg (as perhexiline)
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Perhexiline Maleate Tablets
Ingredients	This product contains perhexiline maleate.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	50mg (as perhexiline)

Registered Holders

OLON S.P.A.

Italy
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