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ASPARTAME

ASPARTAME structure

CAS No:
7421-84-3
Formula:
C14H18N2O5
Chemical Name:
ASPARTAME
Synonyms:
METHYL L-ALPHA-ASPARTYL-L-PHENYLALANINATE

Description

Solid

ChEBI: Aspartame is a dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. It has a role as a sweetening agent, a nutraceutical, a micronutrient, a xenobiotic, an environmental contaminant, an apoptosis inhibitor and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is a dipeptide, a carboxylic acid and a methyl ester. It is functionally related to a L-aspartic acid and a methyl L-phenylalaninate.

ASPARTAME Basic Attributes

Molecular Weight：

Exact Mass：

294.30

Characteristics

PSA：

119

XLogP3：

0.07 (est)

Appearance：

White, odourless, crystalline powder having a sweet taste. Approximately 200 times as sweet as sucrose

Melting Point：

246-247 °C

Water Solubility：

The solubility of aspartame in water is dependent on pH and temperature, the maximum solubility is reached at pH 2.2 (20 mg/mL at 25 °C) and the minimum solubility at pH 5.2 (pHi) is 13.5 mg/mL at 25 °C.

Storage Conditions：

Measures should be taken to minimize the potential for dust explosion.

Vapor Pressure：

2.84X10-11 mm Hg at 25 deg C (est)

Specific rotation：

[α]D/20: + 14,5° to + 16,5°; Determine in a 4 in 100/15 N formic acid solution within 30 minutes after preparation of the sample solution

Odor：

Odorless

Taste：

Sweet

PH：

Between 4,5 and 6,0 (1 in 125 solution)

Safety Information

Stability/Shelf Life：

Differential scanning calorimetry experiments with some directly compressible tablet excipients suggests that aspartame is incompatible with dibasic calcium phosphate and also with the lubricant magnesium stearate. Reactions between aspartame and sugar alcohols are also known.

Precautionary statement(s)：

P260, P261, P264, P270, P271, P280, P302+P352, P304+P312, P304+P340, P312, P314, P322, P363, P501

Hazard Statements：

H312