Schisandrin
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Schisandrin
structure -
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CAS No:
7432-28-2
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Formula:
C24H32O7
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Chemical Name:
Schisandrin
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Synonyms:
Dibenzo[a,c]cycloocten-6-ol,5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S,12aR)-;Schizandrin;(6S,7S,12aR)-5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol;Schisandrin;Schisandrine;Schizandrine;Wuweizichun A;Wuweizi alcohol A;(+)-Schizandrin;Schizandrol;Schisandrol A;11031-50-8;50809-18-2;52932-78-2
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CAS No:
Description
Schisandrin has various therapeutic effects on a range of medical conditions such as anti-asthmatic, anti-cancer, and anti-inflammatory effects.IC50 value:Target:in vitro: Sch inhibited the pro-fibrotic activity of TGF-β1 in AML12 cells; thus, it suppressed the accumulation of ECM proteins. Also, Sch inhibited the EMT as assessed by reduced expression of vimentin and fibronectin, and increased E-cadherin and ZO-1 in TGF-β1 induced AML12 cells. Sch reduced TGF-β1-mediated phosphorylation
Schizandrin is a tannin.
Characteristics
75.61000
3.89090
White powder
1.135 g/cm3
128-129 °C
576.7ºC at 760 mmHg
302.6ºC
1.535
DMSO: ≥13mg/mL
Safety Information
Ⅲ
3077
3
9
60-61
Xn,N
P301 + P312 + P330
H302-H400
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P301+P312, P330, P391, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Schisandrin Use and Manufacturing
It has the functions of sedation and calming, antispasmodic and analgesic, improving microcirculation, anti-myocardial ischemia and narrowing the scope of acute myocardial infarction, anti-pulmonary edema, anti-depression, anti-tumor and antibacterial.
Computed Properties
Molecular Weight:432.5
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:432.21480336
Monoisotopic Mass:432.21480336
Topological Polar Surface Area:75.6
Heavy Atom Count:31
Complexity:574
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Giving mice 20.0ml and 10.0ml/kg body weight of 28-flavor kidney-tonifying oral liquid (equivalent to 11.2g and 5.6g/kg of crude drug, respectively) can significantly improve the sexual function of male mice and increase the number of vaginal plugs in female mice in the same cage. 28-flavor kidney-tonifying capsule (5.4g/kg of crude drug) also has a similar effect. High-dose oral liquid can increase the activity of SOD in the whole blood of mice, indicating that this product has a certain effect on delaying aging. 28-flavor kidney-tonifying capsule also has the same effect, but the effect of oral liquid (raw drug) 11.2g/kg of body weight is better than capsule (5.4g/kg of body weight). Acute toxicity test: 1g of 28-flavor kidney-tonifying oral liquid was given to mice, and the maximum daily tolerance was greater than 90ml/kg (equivalent to 50.4g of crude drug), which is 225 times the daily dose to be used clinically; ip administration, the maximum daily tolerance was greater than 40ml/kg (equivalent to 22.4g of crude drug), indicating that this product has little toxicity. Long-term toxicity test: rats were gavaged with twice-concentrated 28-flavor kidney-tonifying oral liquid, with a maximum daily dose of 15 ml/kg, equivalent to 16.8 g/kg body weight of crude drug, which is 75 times the proposed clinical daily dose. The drug was administered for 12 consecutive weeks. No toxic or adverse reactions were observed in the animal's appearance, body weight, organ coefficient, blood picture, blood biochemistry, and pathological examination of 12 major organ tissues, and no deaths occurred. The proposed clinical dose of this product is safe.
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