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Bithionol sulfoxide

Bithionol sulfoxide structure

CAS No:
844-26-8
Formula:
C12H6Cl4O3S
Chemical Name:
Bithionol sulfoxide
Synonyms:
Phenol,2,2′-sulfinylbis[4,6-dichloro-;2,2′-Sulfinylbis[4,6-dichlorophenol];Bis(2-hydroxy-3,5-dichlorophenyl) sulfoxide;Bis(3,5-dichloro-2-hydroxyphenyl) sulfoxide;Bithionol sulfoxide;2,2′-Dihydroxy-3,3′,5,5′-tetrachlorodiphenyl sulfoxide;Bitin S;3,5,3′,5′-Tetrachloro-2,2′-dihydroxydiphenyl sulfoxide;Distobitin;Disto-5-Cogla;Sulphene;Bithionoloxide;Levacid;NSC 523910;2,4-Dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol;28191-01-7;37372-41-1
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Bithionol sulfoxide(Bitin-S) is a clinically approved anti-parasitic drug; has been shown to inhibit solid tumor growth in several preclinical cancer models.IC50 value:Target: anticaner agentBithionol caused dose dependent cytotoxicity against all ovarian cancer cell lines tested with IC50 values ranging from 19 μM - 60 μM. BT treatment resulted in cell cycle arrest at G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to N

Bithionol sulfoxide Basic Attributes

Molecular Weight：

372.05

Exact Mass：

372.05

EC Number：

212-679-2

UNII：

6PL3DO2B30

NSC Number：

523910

DSSTox ID：

DTXSID5046225

HScode：

2930909090

Characteristics

PSA：

76.74000

XLogP3：

5.74380

Appearance：

Off white to tinch pink crystalline powder

Density：

1.86 g/cm3

Melting Point：

220 °C @ Solvent: Methanol

Boiling Point：

532.7ºC at 760 mmHg

Flash Point：

276ºC

Refractive Index：

1.769

Safety Information

wgk germany：

RTECS Number：

SM8800000

Drug Information

MeSH Entry Terms：

bis(2-hydroxy-3,5-dichlorophenyl)sulfoxide

Computed Properties

Molecular Weight:372.0
XLogP3:5.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:371.876226
Monoisotopic Mass:369.879176
Topological Polar Surface Area:76.7
Heavy Atom Count:20
Complexity:341
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Bithionol sulfoxide

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
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BITHIONOL SULFOXIDE 99% Solid Dideu

CAS No.: 844-26-8

Grade: Pharmaceutical Grade

Content: 99%

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