1-Phenyl-1H-benzotriazole
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1-Phenyl-1H-benzotriazole
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CAS No:
883-39-6
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Formula:
C12H9N3
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Chemical Name:
1-Phenyl-1H-benzotriazole
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Synonyms:
1-Phenyl-1H-benzo[d][1,2,3]triazole;1-Phenylbenzotriazole;1H-Benzotriazole, 1-phenyl-;1-Phenyl-1,2,3-benzotriazole;1-Phenyl-1H-1,2,3-benzotriazole;1-Phenyl-1H-benzotriazole;1 -Phenylbenzotriazole;MLS000701318;SCHEMBL165333;BDBM3793
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CAS No:
Characteristics
30.7
2.8
1.21±0.1 g/cm3(Predicted)
108-109 °C
359.3°C at 760 mmHg
171.1ºC
1.674
3.9 [ug/mL]
1-Phenyl-1H-benzotriazole Use and Manufacturing
General procedure: To a solution of Cu(OAc)General procedure: To a solution of N-heterocycle (1 equiv), bromobenzene (1.02 equiv) and In a 5 mL Schlenk flask, Cs2CO3 (97.7 mg, 0.3 mmol), 18-crown-6 (52.9 mg, 0.2 mmol), 1 mL of acetonitrile, Aromatic alkyne precursor 2a (74.4 mg, 0.3 mmol) andAzidobenzene 3b (23.8 mg, 0.2 mmol), The reaction was stirred at 30 ° C under a nitrogen atmosphere for 12h.After the reaction, silica gel column chromatography to separate and purify, The eluent was petroleum ether (60-90 ° C) / ethyl acetate = 10: 1 (v / v)The target product 4ab (30 mg, yield 77percent) was obtainedUnder nitrogen, the iodobenzene (20.4g, 0.10mol), Pd (dppf) Cl2.CH2Cl2 (0.8g, 0.001mol) andCuI (3.3 g, 0.0173 mol), isopropylamine (200 ml) was added to tetrahydrofuran (500 ml), sodium benzotriazole (15.5 g, 0.11 mol) was slowly added, and the mixture was warmed to 80 ° C and stirred for 12 hours, TLC The reaction was completed, and a silica gel column (PE/EA = 2/1 to 1/1) was obtained to obtain Compound 1 (17.6 g, yield: 91percent).1 -Phenylbenzotriazole