Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1)
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Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1)
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CAS No:
80223-99-0
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Formula:
C20H28N2O5S.ClH
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Chemical Name:
Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1)
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Synonyms:
Benzenesulfonamide,5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-,hydrochloride (1:1);Benzenesulfonamide,5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-,monohydrochloride;YM 12617;LY 253352;dl-Tamsulosin hydrochloride;106463-18-7;112101-80-1
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CAS No:
Description
White to Off-White Solid
A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.
Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1) Basic Attributes
444.97
444.14900
617-011-7
2935909550
Characteristics
108.26000
5.31490
254-256 °C
595.5ºC at 760 mmHg
313.9ºC
In water, 215.9 mg/L at 25 deg C (est)
Store at 25 deg C (77 deg F); excursions permitted to 15-30 deg C (59-86 deg F).
3.96X10-11 mm Hg at 25 deg C (est)
Safety Information
NONH for all modes of transport
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)|Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)
5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide|5-(2-((2-ethoxyphenoxy)ethyl)amino)propyl-2-methoxybenzenesulfonamide
Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1) Use and Manufacturing
Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.
Computed Properties
Molecular Weight:445.0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:11
Exact Mass:444.1485709
Monoisotopic Mass:444.1485709
Topological Polar Surface Area:108
Heavy Atom Count:29
Complexity:539
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Selectively block the (1A adrenaline receptors in the prostate, relax the prostate smooth muscle, and thus improve symptoms such as dysuria caused by benign prostatic hyperplasia
Registered Holders
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Vasudha Pharma Chem Ltd
Active
United States
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SWATI SPENTOSE PRIVATE LTD
Active
United States
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APITORIA PHARMA PRIVATE LTD
Active
United States
Recommended Suppliers of Benzenesulfonamide, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, hydrochloride (1:1)
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