3-Bromo-2,6-difluoropyridine
-
3-Bromo-2,6-difluoropyridine
structure -
-
CAS No:
80392-79-6
-
Formula:
C5H2BrF2N
-
Chemical Name:
3-Bromo-2,6-difluoropyridine
-
Synonyms:
3-Bromo-2,6-difluoropyridine;Pyridine, 3-bromo-2,6-difluoro-;2,6-Difluoro-3-bromopyridine;SCHEMBL9157488;CTK5E7738;DTXSID90599695;KS-00000R5I;MFCD11044274;ZINC44831690;AKOS006307329
- Categories:
-
CAS No:
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
3-Bromo-2,6-difluoropyridine Use and Manufacturing
General procedure: To asolution of 3-bromo-2, 6-dichloropyridine (4.70 g, 20.7 mmol) in DMSO (103 ml)was added cesium fluoride (12.6 g, 82.9 mmol) at room temperature. The mixturewas stirred at 80 °C under air for 8 h. The mixture was poured into water atroom temperature and extracted with EtTo the solution of 3-bromo-2, 6-difluoro-pyridine (5.22 g, 25.57 mmol) in tetrahydrofuran (20 mL) at -78 C under nitrogen was added dropwise w-butyllithium (2.5M, 11 mL, 28 mmol). The reaction was maintained at -78 C for 30 min followed by addition of 2, 2- dimethyloxirane (2.7 ml, 30.7 mmol) and boron trifluoride diethyl etherate (3.9 ml, 30.7 mmol). After 2h at -78 C, the reaction was allowed to rt, quenched with water (200 ml) and extracted with dichloromethane (20 ml*3). The organic phases were combined, concentrated and the residue was purified by silica gel chromatography (eluting gradient 0-30% isopropyl acetate: heptanes) to afford the desired product as a yellow oil (1630 mg, 34% yield). MS (ESI): m/z = 188.1 [M+l]+.
Computed Properties
Molecular Weight:193.98
XLogP3:2.4
Hydrogen Bond Acceptor Count:3
Exact Mass:192.93387
Monoisotopic Mass:192.93387
Topological Polar Surface Area:12.9
Heavy Atom Count:9
Complexity:101
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 3-Bromo-2,6-difluoropyridine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
4 YRS
Business licensed Certified factoryManufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization
Learn More Other Chemicals
-
(2E)-3-(1-METHYL-1H-PYRROL-2-YL)ACRYLIC ACID
51485-76-8
-
Benadryl N-oxide hydrochloride
13168-00-8
-
6-CHLORO-3-IODO-IMIDAZO[1,2-A]PYRIDINE
885275-59-2
-
(2-Bromophenyl)diphenylphosphine Formula
62336-24-7
-
1-Morpholinocyclopentene Formula
936-52-7
-
4-[2-(Boc-amino)ethoxy]-benzoic acid Formula
168892-66-8
-
3-amino-5-bromopyridine-2-carboxylic acid Structure
870997-85-6
-
2-Amino-6-methylpyridine Structure
1824-81-3
-
What is 3-Bromo-2-methylthiophene
30319-05-2
-
What is THIOPHEN-2-YLMETHYL-PHOSPHONICACIDDIETHYLESTER
2026-42-8