2-AMINO-4,6-DIHYDROXY-5-NITROPYRIMIDINE

Yellow-Green Solid

20 g of guanidine hydrochloride was weighed into 500 mL of a reflux condenser, A thermometer and a dropping funnel, Add 200mL mass concentration of 30% sodium methoxide solution, Start the agitator, Stirring at 300r / min for 10min;After the completion of the stirring, 50 mL of a methanol solution having a mass concentration of 80% was added to the flask, The flask was transferred to a water bath, Heating up to 90 C, Reflux 1 ~ 3h through the dropping funnel continue to drop 50mL concentratedDegree of 3mol / L of diethyl malonate solution of methanol, dropping speed control to drop within 30min is completed, Stirring was continued for 10 min;After completion of the stirring, The mixture was allowed to cool naturally to room temperature, Into the Buchner funnel for filtration, Separating the residue into a rotary evaporator, Evaporation gave a white solid, Grinding to obtain white powder;20 g of the above-obtained white powder was weighed into a 500-mL beaker, Continue to add 200mL concentration of 70% concentrated nitric acid, Stir with a glass rod, The beaker is placed on an asbestos web, Heating it with an alcohol lamp, A thermometer was added to the beaker, and the temperature was raised to 70 C, and the heating was stopped. To the above-mentioned beaker, Into 10g sodium hydroxide powder and 2g zinc powder, stir with a glass rod evenly, then dropping through the dropping funnelInto 10mL of 30% concentration of ammonia, placed in the magnetic stirrer at 300r / min speed stirring10min; After stirring, add 30mL of 30% ammonium chloride solution to the beaker, Beaker into the ultrasonic oscillator, the ultrasonic oscillation reaction 1h, the mixture into the rotary evaporator, lWarm to 70 C, rotary evaporation of a light yellow solid, that is 2, 5 - diamino - 4, 6 - dihydroxy pyridine.20 g of guanidine hydrochloride was weighed into 500 mL of a reflux condenser, A thermometer and a dropping funnel, Add 200mL mass concentration of 30% sodium methoxide solution, Start the agitator, Stirring at 300r / min for 10min;After the completion of the stirring, 50 mL of a methanol solution having a mass concentration of 80% was added to the flask, The flask was transferred to a water bath, Heating up to 90 C, Reflux 1 ~ 3h through the dropping funnel continue to drop 50mL concentratedDegree of 3mol / L of diethyl malonate solution of methanol, dropping speed control to drop within 30min is completed, Stirring was continued for 10 min;After completion of the stirring, The mixture was allowed to cool naturally to room temperature, Into the Buchner funnel for filtration, Separating the residue into a rotary evaporator, Evaporation gave a white solid, Grinding to obtain white powder;20 g of the above-obtained white powder was weighed into a 500-mL beaker, Continue to add 200mL concentration of 70% concentrated nitric acid, Stir with a glass rod, The beaker is placed on an asbestos web, Heating it with an alcohol lamp, A thermometer was added to the beaker, and the temperature was raised to 70 C, and the heating was stopped. To the above-mentioned beaker, Into 10g sodium hydroxide powder and 2g zinc powder, stir with a glass rod evenly, then dropping through the dropping funnelInto 10mL of 30% concentration of ammonia, placed in the magnetic stirrer at 300r / min speed stirring10min; After stirring, add 30mL of 30% ammonium chloride solution to the beaker, Beaker into the ultrasonic oscillator, the ultrasonic oscillation reaction 1h, the mixture into the rotary evaporator, lWarm to 70 C, rotary evaporation of a light yellow solid, that is 2, 5 - diamino - 4, 6 - dihydroxy pyridine.2-Amino-6-(2-amino-2-methylpropylamino)-4-hydroxy-5-nitropyrimidine monohydrochloride (IIIa) 2-Amino-6-chloro-4-hydroxy-5-nitropyrimidine, 1.94 g, was finely powdered and dissolved in approximately 200 ml boiling absolute ethanol and filtered while hot to remove the insoluble

Molecular Weight:172.10
XLogP3:-0.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Exact Mass:172.02325462
Monoisotopic Mass:172.02325462
Topological Polar Surface Area:134
Heavy Atom Count:12
Complexity:312
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes