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5,7,4′-Trimethoxyflavone

5,7,4′-Trimethoxyflavone structure

CAS No:
5631-70-9
Formula:
C18H16O5
Chemical Name:
5,7,4′-Trimethoxyflavone
Synonyms:
4H-1-Benzopyran-4-one,5,7-dimethoxy-2-(4-methoxyphenyl)-;Flavone,4′,5,7-trimethoxy-;5,7-Dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;4′,5,7-Trimethoxyflavone;Tri-O-methylapigenin;Trimethylapigenin;5,7,4′-Trimethoxyapigenin;5,7,4′-Trimethoxyflavone;5,7-Dimethoxy-2-(4-methoxyphenyl)chromone;5,7-Dimethoxy-4-oxo-2-(4-methoxyphenyl)-4H-1-benzopyran;Apigenin trimethyl ether;5,7,4′-Tri-O-methylapigenin;5,7-Dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

5,7,4'-Trimethoxyflavone is isolated from Kaempferia parviflora (KP) that is a famous medicinal plant from Thailand. 5,7,4'-Trimethoxyflavone induces apoptosis, as evidenced by increments of sub-G1 phase, DNA fragmentation, annexin-V/PI staining, the Bax/Bcl-xL ratio, proteolytic activation of caspase-3, and degradation of poly (ADP-ribose) polymerase (PARP) protein.5,7,4'-Trimethoxyflavone is significantly effective at inhibiting proliferation of SNU-16 human gastric cancer cells in a c

Solid

4',5,7-Trimethoxyflavone is an ether and a member of flavonoids.

5,7,4′-Trimethoxyflavone Basic Attributes

Molecular Weight：

312.31700

Exact Mass：

312.32

UNII：

F50JU8E74U

DSSTox ID：

DTXSID10204855

HScode：

2932999099

Characteristics

PSA：

57.90000

XLogP3：

3.48580

Appearance：

Solid

Density：

1.242g/cm3

Melting Point：

152-154 °C @ Solvent: Ethyl acetate

Boiling Point：

506.5ºC at 760mmHg

Flash Point：

225.5ºC

Refractive Index：

1.585

Water Solubility：

6.512 mg/L @ 25 °C (est)

Drug Information

MeSH Entry Terms：

4',5,7-trimethoxyflavone

5,7,4′-Trimethoxyflavone Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:312.3
XLogP3:2.2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:312.09977361
Monoisotopic Mass:312.09977361
Topological Polar Surface Area:54
Heavy Atom Count:23
Complexity:452
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5,7,4′-Trimethoxyflavone

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4,5,7-TRIMETHOXYFLAVONE

CAS No.: 5631-70-9

Content: 99.00%

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Guide of 5,7,4′-Trimethoxyflavone

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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5,7,4′-Trimethoxyflavone

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