Loteprednol etabonate
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Loteprednol etabonate
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CAS No:
82034-46-6
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Formula:
C24H31ClO7
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Chemical Name:
Loteprednol etabonate
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Synonyms:
Androsta-1,4-diene-17-carboxylic acid,17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-,chloromethyl ester,(11β,17α)-;HGP 1;CDDD 5604;P 5604;Loteprednol etabonate;Lenoxin;Alrex;Lotemax
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CAS No:
Description
Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no i
Characteristics
99.13000
3.17
white to beige
1.3±0.1 g/cm3
220.5-223.5 °C
600.1±55.0 °C at 760 mmHg
316.7±31.5 °C
1.571
DMSO: soluble5mg/mL, clear (warmed)
-20°C Freezer
Safety Information
NONH for all modes of transport
3
|Warning|H302 (20%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P261, P263, P264, P270, P271, P273, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P314, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 7 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Loteprednol etabonate Use and Manufacturing
Biological Activity Chemical Information Tech Support & FAQs Biological Activity Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology.It is used for the treatment of steroid responsive inflammatory conditions of the eye su
Computed Properties
Molecular Weight:466.9
XLogP3:3.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:466.1758310
Monoisotopic Mass:466.1758310
Topological Polar Surface Area:99.1
Heavy Atom Count:32
Complexity:882
Undefined Atom Stereocenter Count:7
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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