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(+)-Metoprolol

(+)-Metoprolol structure

CAS No:
81024-43-3
Formula:
C15H25NO3
Chemical Name:
(+)-Metoprolol
Synonyms:
2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-,(2R)-;2-Propanol,1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-,(R)-;(2R)-1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol;(R)-(+)-Metoprolol;(+)-Metoprolol;(R)-Metoprolol;2-Propanol 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-,(2R)-;91324-77-5
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

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Description

Light Beige Waxy Solid

(+)-Metoprolol Basic Attributes

Molecular Weight：

267.36

Exact Mass：

267.36

DSSTox ID：

DTXSID20230862

Characteristics

PSA：

50.7

XLogP3：

1.79

Density：

1.0±0.1 g/cm3

Melting Point：

39-42°C

Boiling Point：

398.6±37.0 °C at 760 mmHg

Flash Point：

194.9±26.5 °C

Refractive Index：

1.508

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Drug Information

Metabolism/Metabolites：

(r)-metoprolol has known human metabolites that include N_DEISOPROPYLATION, O-Demethylmetoprolol, and alpha-Hydroxymetoprolol.

(+)-Metoprolol Use and Manufacturing

(R)-Enantiomer of Metoprolol. Antihypertensive; antianginal; antiarrhythmic (class II)

Computed Properties

Molecular Weight:267.36
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:267.18344366
Monoisotopic Mass:267.18344366
Topological Polar Surface Area:50.7
Heavy Atom Count:19
Complexity:215
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes