Bis(sulfosuccinimidyl) suberate
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Bis(sulfosuccinimidyl) suberate
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CAS No:
82436-77-9
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Formula:
C16H20N2O14S2
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Chemical Name:
Bis(sulfosuccinimidyl) suberate
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Synonyms:
Octanedioic acid,1,8-bis(2,5-dioxo-3-sulfo-1-pyrrolidinyl) ester;3-Pyrrolidinesulfonic acid,1,1′-[(1,8-dioxo-1,8-octanediyl)bis(oxy)]bis[2,5-dioxo-;Bis(sulfosuccinimidyl) suberate;Di(sulfosuccinimidyl) suberate;Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester)
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CAS No:
Description
BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Safety Information
NONH for all modes of transport
36/37/38
26-36-24/25-22
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. (See all compounds classified as Cross-Linking Reagents.)
bis succinylsuberate BS(3)
Bis(sulfosuccinimidyl) suberate Use and Manufacturing
A water-soluble protein cross-linker for: cross-linking and targeting of mouse erythrocytes, receptor-ligand cross-linking, cross-linking of calveolin proteins, cross-linking of growth factors to proteinase inhibitor, and cross-linking of glass bead
Computed Properties
Molecular Weight:528.5
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:13
Exact Mass:528.03559566
Monoisotopic Mass:528.03559566
Topological Polar Surface Area:253
Heavy Atom Count:34
Complexity:1010
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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