 Home > Encyclopedia > Moexipril hydrochloride

Moexipril hydrochloride

Moexipril hydrochloride structure

CAS No:
82586-52-5
Formula:
C27H34N2O7.ClH
Chemical Name:
Moexipril hydrochloride
Synonyms:
3-Isoquinolinecarboxylic acid,2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,hydrochloride (1:1),(3S)-;3-Isoquinolinecarboxylic acid,2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,monohydrochloride,[3S-[2[R*(R*)],3R*]]-;3-Isoquinolinecarboxylic acid,2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-,monohydrochloride,(3S)-;SPM 925;CI 925;Univasc;RS 10085-197;Moexipril hydrochloride;Primox
Categories:
Biochemical Engineering > Inhibitors

Description

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme(ACE) inhibitor, which is used for the treatment of hypertension and congestive heart failure. Target: ACEMoexipril is a long-acting ACE inhibitor suitable for once-daily administration, and like some ACE inhibitors, moexipril is a prodrug and needs to be hydrolyzed in the liver into its active carboxylic metabolite, moexiprilat, to become effective [1]. Upon oral administration of moexipril (10 mg/kg/day

Moexipril hydrochloride is a dipeptide.|Moexipril Hydrochloride is the hydrochloride salt form of moexipril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Moexipril hydrochloride is hydrolized into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilatation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. Moexipril hydrochloride also directly suppresses renin release.

Moexipril hydrochloride Basic Attributes

Molecular Weight：

535.03

Exact Mass：

534.213

EC Number：

1312995-182-4

UNII：

Q1UMG3UH45

DSSTox ID：

DTXSID7044267

NCI Thesaurus Code：

C29267

HScode：

2933492250

Characteristics

PSA：

114.40000

XLogP3：

3.71510

Appearance：

a fine white to off-white powder

Melting Point：

141-1610C

Boiling Point：

709.3ºC at 760 mmHg

Flash Point：

382.8ºC

Water Solubility：

H2O: soluble 32mg/mL

Storage Conditions：

2-8°C

Specific rotation：

D23 +34.2° (c = 1.1 in ethanol)

Safety Information

Transport codes：

UN30779/PG3

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

NW7174500

Marks：

Precautionary statement(s)：

P273

Hazard Statements：

H400

GHS Classification：

|Warning|H400 (95%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|P273, P391, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

2-((1-ethoxycarbony)-3-phenylpropylamino-1-oxopropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Moexipril hydrochloride Use and Manufacturing

Uses

Moexipril HCl is a potent orally active non-sulfhydryl angiotensin converting enzyme inhibitor (ACE) with IC50 of 0.041 μM, which is used for the treatment of hypertension and congestive heart failure

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:535.0
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:12
Exact Mass:534.2132792
Monoisotopic Mass:534.2132792
Topological Polar Surface Area:114
Heavy Atom Count:37
Complexity:742
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Moexipril hydrochloride

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Moexipril hydrochloride

CAS No.: 82586-52-5

Content: 99.00%

Inquiry