Pralidoxime iodide
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Pralidoxime iodide
structure -
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CAS No:
94-63-3
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Formula:
C7H9N2O.I
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Chemical Name:
Pralidoxime iodide
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Synonyms:
Pyridinium,2-[(hydroxyimino)methyl]-1-methyl-,iodide (1:1);2-Formyl-1-methylpyridinium iodide oxime;Pyridinium,2-formyl-1-methyl-,iodide,oxime;Pyridinium,2-[(hydroxyimino)methyl]-1-methyl-,iodide;2-PAM;1-Methyl-2-aldoximinopyridinium iodide;1-Methyl-2-hydroxyiminomethylpyridinium iodide;N-Methylpyridinium-2-aldoxime iodide;PAM;Pralidoxime iodide;Protopam iodide;2-Pyridine aldoxime iodomethylate;2-Pyridinealdoxime methiodide;2-Pyridine aldoxymethiodide;PAM (pharmaceutical);2-Hydroxyiminomethyl-1-methylpyridinium iodide;N-Methylpyridine-2-aldoxime iodide;Pyridinium-2-aldoxime N-methyliodide;Pralidoxime methiodide;2-Pyridine aldoxime methyl iodide;2-Pyridinecarboxaldehyde aldoxime methiodide;2-Pyridylaldoxime methiodide;Pyridine aldoxime methiodide;2-(Hydroximinomethyl)-1-methylpyridinium iodide;2-PAM iodide;2-Pyridinaldoxime methiodide;Pralidoxime iodomethylate
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CAS No:
Description
Pralidoxime iodide is a reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent, which inhibits AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning[1][2].
Characteristics
36.47000
-2.67680
1.7439 (estimate)
225-226 °C
2-8°C
LD50 in mice (mg/kg): 140-178 i.v., 136-260 i.p., 290-340 s.c., 1500-4000 orally (Ellin, Wills)
Safety Information
NONH for all modes of transport
3
22
36-24
UU4375000
Xn
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:264.06
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:263.97596
Monoisotopic Mass:263.97596
Topological Polar Surface Area:36.5
Heavy Atom Count:11
Complexity:125
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extracting pharmacological effects from the above information
Registered Holders
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Kaifeng Pharmaceutical (GROUP) Co., Ltd.
Active
China
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China Resources Double-Crane Pharmaceutical Co., Ltd.
Active
China
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Chengdu Sino-Strong Pharmaceutical Co., Ltd.
Active
China
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