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Bryostatin 1

Bryostatin 1 structure

CAS No:
83314-01-6
Formula:
C47H68O17
Chemical Name:
Bryostatin 1
Synonyms:
2,4-Octadienoic acid,(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester,(2E,4E)-;Bryostatin 1;18,27,28,29-Tetraoxatetracyclo[21.3.1.13,7.111,15]nonacosane,bryostatin 1 deriv.;2,4-Octadienoic acid,25-(acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester,[1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-;[1S-[1R*,3R*,5Z,7S*,8E,11R*,12R*(2E,4E),13E,15R*,17S*(S*),21S*,23S*,25R*]]-25-(Acetyloxy)-1,11,21-trihydroxy-17-(1-hydroxyethyl)-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl 2,4-octadienoate;NSC 339555
Categories:
Organic Chemistry > Lactones

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Bryostatin 1 Basic Attributes

Molecular Weight：

905.0

Exact Mass：

905.03

DSSTox ID：

DTXSID8046876

Characteristics

Water Solubility：

t-Butanol > 9.2 (mg/mL)|50% Butanol/water > 3.0 (mg/mL)|PET solvent* > 2.8 (mg/mL)|Soybean oil 1.5 - 3.0 (mg/mL)|*PEG 400 (60mL)/EtOH (30mL)/Tween 80 (10 mL) (mg/mL)

Safety Information

Stability/Shelf Life：

Solution: Samples dissolved in PET solvent and t- Butanol showed no degradation after storage for 24 and 48 hr at ambient temperature. Samples dissolved in these same solvents showed no degradation after storage at 50 °C for 23 hr.

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

MeSH Entry Terms：

bryostatin 1