2-Ethoxybenzamide
-
2-Ethoxybenzamide
structure -
-
CAS No:
938-73-8
-
Formula:
C9H11NO2
-
Chemical Name:
2-Ethoxybenzamide
-
Synonyms:
Benzamide,2-ethoxy-;Benzamide,o-ethoxy-;2-Ethoxybenzamide;Ethenzamide;Ethosalicyl;o-Ethoxybenzamide;Etosalicyl;Ethbenzamide;Lucamide;Protopyrin;Trancalgyl;Etamide;Pirosolvina;Ethenzamid;Etocil;Etosalicil;Eusal;Katagrippe;NSC 28787;Etenzamide
- Categories:
-
CAS No:
Description
2-Ethoxybenzamide is widely used as an antipyretic anodyne.
2-ethoxybenzamide appears as white or almost-white crystalline powder. Almost odorless. Tasteless. (NTP, 1992)
2-ethoxybenzamide appears as white or almost-white crystalline powder. Almost odorless. Tasteless. (NTP, 1992)|Ethenzamide is an organic molecular entity.
2-Ethoxybenzamide Basic Attributes
165.19
165.19
213-346-4
L929ZCK4BF
28787
DTXSID4020581
N - Nervous system
29242995
Characteristics
52.3
1.2
White to almost white Granular Crystalline Powder
1.1±0.1 g/cm3
133 °C
302°C at 760 mmHg
153.7±19.5 °C
1.538
H2O: <0.1 g/100 mL at 16 ºC
Store below +30°C.
LD50 orally in mice: 1160 mg/kg (Starmer)
Insoluble in water.
Amides and Imides
2-ETHOXYBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Safety Information
NONH for all modes of transport
2
24/25
CU4381000
Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under ambient temperatures. (NTP, 1992)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
2-ethoxy-benzamide
2-Ethoxybenzamide Use and Manufacturing
It is derived from salicylamide (C7H7NO2, [65-45-2]) by ethylation. Put salicylamide, solid sodium hydroxide and ethanol in a reactor, airtightly heat up to 60-70°C, stir for 30min, cool to 30°C, add bromoethane, and then airtightly heat up to 80-100°C without pressure Over 0.2MPa, react for 3h. The pH should be above 8.5 when it drops to normal pressure. Filter while hot, and recover the filter residue with sodium bromide. After most of the ethanol was evaporated from the filtrate, white crystals were precipitated by adding distilled water. Filter, wash with water until neutral, and dry to obtain o-ethoxybenzamide. The yield is about 75%. Ethyl chloride can also be used instead of ethyl bromide to carry out the ethylation reaction, but higher pressure is required.
This product is an antipyretic analgesic, and its analgesic effect is 2.3 times that of salicylate and 7.5 times that of aspirin. It is used to treat headache, neuralgia, low back pain, rheumatic arthralgia and colds. The oral LD50 of rats is 1160mg/kg. Used as an antipyretic analgesic for the treatment of fever, headache, neuralgia, arthralgia, rheumatoid arthritis, toothache, dysmenorrhea, etc.
Benzamide, 2-ethoxy-: INACTIVE
Computed Properties
Molecular Weight:165.19
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:165.078978594
Monoisotopic Mass:165.078978594
Topological Polar Surface Area:52.3
Heavy Atom Count:12
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
No specific description provided
Registered Holders
-
スペラネクサス株式会社
Active
Japan
-
山本化学工業株式会社
Active
Japan
-
Fuxiang (Dalian) Pharmaceutical Co., Ltd.
Active
China
Recommended Suppliers of 2-Ethoxybenzamide
-
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
2,4-Dichloro-3-methylpyridine
132097-09-7
-
2,6-Dibromo-3-fluoropyridine
41404-59-5
-
Triphenylacetic acid
595-91-5
-
3-Chloro-5-fluoro-4-pyridinecarboxylic acid Formula
514798-03-9
-
2-CHLORO-4-PHENYLPYRIDINE Formula
42260-39-9
-
2-Phenyl-4-quinolinecarboxylic acid Formula
132-60-5
-
(-)-Flurbiprofen Structure
51543-40-9
-
Naproxen sodium Structure
26159-34-2
-
What is Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester, hydrochloride (1:1)
66532-86-3
-
What is 2-[(3-Chlorophenyl)amino]benzoic acid
13278-36-9