Glycine methyl ester hydrochloride
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Glycine methyl ester hydrochloride
structure -
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CAS No:
5680-79-5
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Formula:
C3H7NO2.ClH
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Chemical Name:
Glycine methyl ester hydrochloride
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Synonyms:
Glycine,methyl ester,hydrochloride (1:1);Glycine,methyl ester,hydrochloride;Methyl glycinate hydrochloride;Aminoacetic acid methyl ester hydrochloride;Methyl aminoacetate hydrochloride;Glycine methyl ester monohydrochloride;Methyl α-aminoacetate hydrochloride;Methyl 2-aminoacetate hydrochloride;2-Aminoacetic acid methyl ester hydrochloride;Glycine methyl ester hydrochloride;2099112-83-9
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CAS No:
Glycine methyl ester hydrochloride Basic Attributes
125.55
125.024353
3593644
227-139-1
9229
DTXSID20205358
29224995
Characteristics
52.3
0.62040
White Powder or Cyrstals
1.000
175-176 °C
82.1ºC at 760 mmHg
H2O: >1000 g/L (20 ºC)
-20°C
Safety Information
NONH for all modes of transport
3
22-24/25
Stable. Incompatible with strong oxidizing agents.
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Glycine methyl ester hydrochloride Use and Manufacturing
Can be prepared with glycine or chloroacetic acid as raw materials. It is described as follows. Glycine is used as the raw material method. Dry hydrogen chloride gas is passed into absolute ethanol to make hydrogen chloride ethanol solution, then glycine is added, heated and stirred for esterification, and the reaction temperature is controlled at 80-85°C. After all the glycine is dissolved, stirring A few minutes, while hot, move the reaction solution to the crystallization pot, cool the crystallization, and filter to obtain ethyl glycine hydrochloride. Reaction equation: NH2CH2COOH+C2H5O[HCl]→NH2CH2COOC2H5·HCl can also be added to the reactor with stirring glycine and absolute ethanol, heated to 60 ℃, through the introduction of hydrogen chloride gas, hydrogen chloride until the reactants are completely dissolved, continue After passing hydrogen chloride to recrystallization, it is the end point. The reaction solution is transferred to the crystallization pot, while stirring, the crystal is cooled and filtered, washed with absolute ethanol, and dried to obtain ethyl glycine hydrochloride. Chloroacetic acid is used as the raw material method. Chloroacetic acid, urotropine and absolute ethanol are added to the reactor. At 45℃, ammonia gas is passed to make pH=8～8.5. The rate of ammonia gas is controlled to maintain the reaction temperature at Between 40 and 65°C, after the ammonia gas has been passed through, the reaction is held at 65°C for 1 hour, then the temperature is reduced to 30°C, and the hydrogen chloride-anhydrous ethanol solution is added dropwise. After the dropwise addition, react at 70℃ for 2h, then filter hot at 62～65℃ to separate the ammonium chloride crystals. The filtrate is placed in a crystallization pot, cooled to 10℃, crystallized while stirring, the crystals are filtered, Dry to give ethyl glycine hydrochloride. Reaction equation: ClCH2COOH + NH3 [ethanol] → NH2CH2COOH [C2H5OH] → [HCl] NH2CH2COOH · HCl, using methanol instead of ethanol to obtain glycine methyl ester hydrochloride. Reaction equation: NH2CH2COOH+CH3OH[HCl]→NH2CH2COOCH3·HCl
A Glycine ester, a non-essential amino acid for human development.
Computed Properties
Molecular Weight:125.55
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:125.0243562
Monoisotopic Mass:125.0243562
Topological Polar Surface Area:52.3
Heavy Atom Count:7
Complexity:52.8
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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Glycine methyl ester hydrochloride
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