2-Bromo-6-chloro-4-nitroaniline

A solution of 345 mg (2 mmol) of 2-chloro-4-nitroaniline, 143 mg (1.2 mmol) of potassium bromide was added to 50 ml of three neck The flask was then added with 10 ml of AcOH: H2O = 9: 1 solvent and transferred to a constant temperature magnetic stirring water bath. The control temperature wasThe reaction was stirred at 30 ° C for 1 hour, and 1.8 g (1.8 mmol) of ZnAl-BrO3 - LDHs was slowly added in portions 15 minutes before the reaction. anti- After completion, the reaction solution was extracted with dichloromethane, the organic phases were combined, and two syrups were added to the dichloromethane phase to separate the silica gel(200-300 mesh) and the dichloromethane was distilled off under reduced pressure, and the residue was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1 as Eluent) to give a pure product, 478 mg. The material was a yellow solid in 95percent yield.A solution of 345 mg (2 mmol) of 2-chloro-4-nitroaniline, 143 mg (1.2 mmol) of potassium bromide was added to 50 ml of three neck The flask was then added with 10 ml of AcOH: H2O = 9: 1 solvent and transferred to a constant temperature magnetic stirring water bath. The control temperature wasThe reaction was stirred at 30 ° C for 1 hour, and 1.8 g (1.8 mmol) of ZnAl-BrO3 - LDHs was slowly added in portions 15 minutes before the reaction. anti- After completion, the reaction solution was extracted with dichloromethane, the organic phases were combined, and two syrups were added to the dichloromethane phase to separate the silica gel(200-300 mesh) and the dichloromethane was distilled off under reduced pressure, and the residue was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1 as Eluent) to give a pure product, 478 mg. The material was a yellow solid in 95percent yield.

Used as an intermediate in organic synthesis

Molecular Weight:251.46
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:249.91447
Monoisotopic Mass:249.91447
Topological Polar Surface Area:71.8
Heavy Atom Count:12
Complexity:187
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes