Chelidonic acid
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Chelidonic acid
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CAS No:
99-32-1
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Formula:
C7H4O6
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Chemical Name:
Chelidonic acid
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Synonyms:
4H-Pyran-2,6-dicarboxylic acid,4-oxo-;Chelidonic acid;4-Oxo-4H-pyran-2,6-dicarboxylic acid;Jerva acid;Jervaic acid;Jervasic acid;4-Oxo-1,4-pyran-2,6-dicarboxylic acid;γ-Pyrone-2,6-dicarboxylic acid;2,6-Dicarboxy-4-pyrone;4-Pyranone-2,6-dicarboxylic acid;NSC 3979
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CAS No:
Description
Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].
Chelidonic acid is a carbonyl compound and a member of pyrans.
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
UP7350000
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Chelidonic acid Use and Manufacturing
From the reaction of diethyl oxalate and acetone.
Used in organic synthesis.
Computed Properties
Molecular Weight:184.10
XLogP3:-0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:184.00078784
Monoisotopic Mass:184.00078784
Topological Polar Surface Area:101
Heavy Atom Count:13
Complexity:316
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
It has a significant inhibitory effect on pain and can inhibit inflammatory responses. It has a certain sedative effect on mice. When used in combination with cyclophosphamide, it can increase the tumor inhibition rate and prolong survival time. It has no tolerance and physical dependence.
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