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Splitomicin

Splitomicin structure

CAS No:
5690-03-9
Formula:
C13H10O2
Chemical Name:
Splitomicin
Synonyms:
3H-Naphtho[2,1-b]pyran-3-one,1,2-dihydro-;1-Naphthalenepropionic acid,2-hydroxy-,δ-lactone;1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one;1-Naphthalenepropanoic acid,2-hydroxy-,δ-lactone;Splitomicin;Splitomycin;1,2-Dihydro-3H-benzo[f]chromen-3-one;1,2-Dihydrobenzo[f]chromen-3-one
Categories:
Biochemical Engineering > Inhibitors

Description

Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].

Splitomicin is a benzochromenone that is 2,3-dihydro-1H-benzo[f]chromene substituted by an oxo group at position 3. It has been found to exhibit potential inhibitory activity against Sir2 proteins. It has a role as a Sir2 inhibitor and a platelet aggregation inhibitor. It is a benzochromenone, a delta-lactone and a naphtho-alpha-pyrone.

Splitomicin Basic Attributes

Molecular Weight：

198.2173

Exact Mass：

198.22

HScode：

2914399090

Characteristics

PSA：

26.3

XLogP3：

3.03

Appearance：

solid

Density：

1.3±0.1 g/cm3

Melting Point：

73-74.5 °C

Boiling Point：

155-158 °C @ Press: 0.01 Torr

Flash Point：

161.2±18.4 °C

Refractive Index：

1.656

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH Entry Terms：

splitomicin

Computed Properties

Molecular Weight:198.22
XLogP3:2.9
Hydrogen Bond Acceptor Count:2
Exact Mass:198.068079557
Monoisotopic Mass:198.068079557
Topological Polar Surface Area:26.3
Heavy Atom Count:15
Complexity:261
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Splitomicin

CAS No.: 5690-03-9

Content: 95%

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