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N-Phenylanthranilic acid

N-Phenylanthranilic acid structure

CAS No:
91-40-7
Formula:
C13H11NO2
Chemical Name:
N-Phenylanthranilic acid
Synonyms:
Benzoic acid,2-(phenylamino)-;Anthranilic acid,N-phenyl-;2-(Phenylamino)benzoic acid;o-Anilinobenzoic acid;2-Anilinobenzoic acid;Diphenylamine-2-carboxylic acid;Fenamic acid;2-Carboxydiphenylamine;N-Phenylanthranilic acid;N-Phenyl-o-aminobenzoic acid;N-Phenyl-2-aminobenzoic acid;o-Carboxydiphenylamine;Diphenylamine-2-carboxylate;o-(Phenylamino)benzoic acid;NSC 215211;NSC 4273;DPC;DPC (chloride channel inhibitor)
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

LIGHT GREY-GREEN TO YELLOW-GREEN FINE POWDER

Fenamic acid is an aminobenzoic acid that is the N-phenyl derivative of anthranilic acid. It acts as a parent skeleton for the synthesis of several non-steroidal anti-inflammatory drugs. It has a role as a membrane transport modulator. It is a secondary amino compound and an aminobenzoic acid. It derives from an anthranilic acid.

N-Phenylanthranilic acid Basic Attributes

Molecular Weight：

213.23

Exact Mass：

213.23

EC Number：

202-066-8

UNII：

952VN06WBB

NSC Number：

215211|4273

DSSTox ID：

DTXSID6059025

HScode：

2922499990

Characteristics

PSA：

49.3

XLogP3：

4.4

Appearance：

White to off-white crystalline powder

Density：

1.3±0.1 g/cm3

Melting Point：

183.5 °C

Flash Point：

186.7±23.2 °C

Refractive Index：

1.667

Water Solubility：

insoluble

Storage Conditions：

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Toxicity：

LD50 ipr-mus: 235 mg/kg RPTOAN 37,105,74

Collision Cross Section：

144.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36-S24/25

RTECS Number：

CB3730000

Marks：

Xi:Irritant;

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

MeSH Entry Terms：

4-(phenylamino)benzoic acid

N-Phenylanthranilic acid Use and Manufacturing

Uses

ion channel (Cl) blocker Detection of vanadium in steel.

Manufacturing Info：

Benzoic acid, 2-(phenylamino)-: ACTIVE

Computed Properties

Molecular Weight:213.23
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:213.078978594
Monoisotopic Mass:213.078978594
Topological Polar Surface Area:49.3
Heavy Atom Count:16
Complexity:236
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 91-40-7

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Content: 99%

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