2-Amino-5-chloro-3-nitropyridine
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2-Amino-5-chloro-3-nitropyridine
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CAS No:
5409-39-2
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Formula:
C5H4ClN3O2
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Chemical Name:
2-Amino-5-chloro-3-nitropyridine
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Synonyms:
TIMTEC-BB SBB003813;2-Amino-5-chloro-3-nitrpyridine;5-CHLORO-3-NITROPYRIDIN-2-AMINE;5-Chloro-3-nitro-2-aminopyridine;2-AMINO-5-CHLORO-3-NITROPYRIDINE;5-Chloro-3-nitro-[2]pyridylamine;2-Amino-3-nitro-5-chloro pyridine;2-PYRIDINAMINE, 5-CHLORO-3-NITRO-;5-CHLORO-3-NITRO-PYRIDIN-2-YLAMINE;2-Amino-5-chloro-3-nitropyridine,97%
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CAS No:
Characteristics
84.7
1.5
yellow crystalline powder
1.6±0.1 g/cm3
193-197 °C(lit.)
260.7°C at 760 mmHg
138.7±26.5 °C
1.658
0.000805mmHg at 25°C
Safety Information
IRRITANT
NONH for all modes of transport
3
36/37/38-20/21/22
26-36
Xi,Xn
Irritant
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (97.73%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Amino-5-chloro-3-nitropyridine Use and Manufacturing
To a mixture of 2-amino-5-chloropyridine (2.57 g, 20.0 mmol) and sulfuric acid (6.30 ml), huming HNOTo a 250 mL 3 necked RK flask charged with conc.H2S04 (30 mL) at 0CC, 5 chloropyridin-2-amine (12.5 g) was added portion wise and allowed to stir for 1 h and heated at 50 00 to dissolve starting material completely. Then, conc. HNO3 (8 mL) was added drop wise through addition funnel. The reaction was monitored by every 10 minutes. After completion, 40percent sodium hydroxide solution (pH=6-7) was added, the product was extracted with ethyl acetate, washed with water, and dried over anhydrous Na2SO4. The solvent was removed under vacuo to yield the product (11 .0 g, 51.0percent) as a pale green solid. LCMS: (M-H) = 172.9To a 250 mL 3 necked RK flask charged with conc.H2S04 (30 mL) at 000, 5 chloropyridin-2-amine (12.5 g) was added portion wise and solution was allowed to stir for 1 h and heated at 50 00 to dissolve starting material completely. Then, conc. HNO3 (8 mL) was added drop wise to the resulting solution through addition funnel. The reaction was monitored at every 10 minutes. After completion, 40percent sodiumhydroxide solution (PH=6-7) was added, the product was extracted with ethyl acetate, washed with water, and dried over anhydrous Na2SO4. The solvent was removed under vacuo to yield the product (11.0 g, 51.0percent) as a pale green solid. LOMS: (M-H) = 172.9
Computed Properties
Molecular Weight:173.56
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:172.9992041
Monoisotopic Mass:172.9992041
Topological Polar Surface Area:84.7
Heavy Atom Count:11
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2-Amino-5-chloro-3-nitropyridine
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