Bleomycin sulfate

Bleomycin sulfate is a DNA synthesis inhibitor with potent antitumor activity.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

The product is extracted from St. Verticillus (Str. Verticillus), and the same antibiotic was isolated from Actinomycete 72 in my country. The production process is tertiary fermentation, the medium is starch, glucose, soybean cake powder, yeast powder, corn steep liquor, sodium chloride, zinc sulfate, copper sulfate, potassium dihydrogen phosphate, and the glucose mother liquor is supplemented every 8 hours during the fermentation process. Control the residual sugar in the fermentation broth at about 1%. After the pH rises, the corn syrup will be supplemented every 8h. The amount of supplementation is 0.5% each time. No foam is generated during the fermentation of bleomycin, so no anti-foam oil is needed. In the refining process, bleomycin can be dissociated into cations in aqueous solution, and the weak acid acrylic cation exchange resin is used for separation. In the methanol solution, phenylhydrazine thiocarbonyl azobenzene is used as a chelating agent, or Hydrogen sulfide removes copper ions, repeatedly precipitated with acetone, filtered after refining, and vacuum dried to obtain the finished product.

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Molecular Weight:1512.6
Hydrogen Bond Donor Count:21
Hydrogen Bond Acceptor Count:35
Rotatable Bond Count:36
Exact Mass:1511.4785360
Monoisotopic Mass:1511.4785360
Topological Polar Surface Area:770
Heavy Atom Count:101
Complexity:2660
Defined Atom Stereocenter Count:10
Undefined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes