Ficin
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Ficin
structure -
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CAS No:
9001-33-6
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Chemical Name:
Ficin
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Synonyms:
Ficin;Debricin;Higueroxyl Delabarre;E.C. 3.4.22.3;E.C. 3.4.4.12;Ficain
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CAS No:
Description
Buff to cream-colored powder; acrid odor. Very hygroscopic. Partially soluble in water; insoluble in organic solvents.
A sulfhydryl proteinase with cysteine at the active site from ficus latex. Preferential cleavage is at tyrosine and phenylalanine residues. EC 3.4.22.3.
Characteristics
23.8
-2.17
tan saline suspension
1.4±0.1 g/cm3
656.2±55.0 °C at 760 mmHg
350.7±31.5 °C
1.591
soluble in cold water.
2-8°C
LD50 orally in rats, mice: ~10 g/kg; in rabbits, guinea pigs: ~5 g/kg (Molitor)
Safety Information
NONH for all modes of transport
3
36/37/38-42
26-36-36/37-24-22-45-23
LK3675000
Xn,Xi
P261-P342 + P311
H334
|Danger|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P337+P313, P342+P311, P362, P403+P233, P405, and P501|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|Aggregated GHS information provided by 48 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Ficin Use and Manufacturing
The latex of the fig tree (Ficus sp.) and the milk of immature fruit were extracted with pH 4.0 water, and salted out with ammonium sulfate (secondary) in the presence of ethylenediaminetetraacetic acid (EDTA) and reused The salt is salted out twice. The yield is about 11%. A green fig weighing 10-15g may contain 100-150mg commercial fig protease. After drying in the sun, it has only about 12% viability, and the dried fruit at 100°C is inactive.
Protein digestant.In the brewing industry as a chill proofing agent in beer.In the cheese industry as a substitute for rennet in the coagulation of milk.In the meat industry as a meat tenderizer and as an agent for removing casings from formed sausage.In the leather industry for the bating of leather.In the textile industry for shrinkproofing wool, for removing gelatin from sized thread, and mixed with amylases and maltases as a spot remover.In the preparation of peptones.For solubilizing protein material in spent grains.Also used in the determination of the Rh factor.Speeds 10 times the agglutination of human blood cells by the Rh factor when in contact with the anti-Rh serum.
Ficin: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).
Food Additives -> ENZYME_PREPARATION; -> JECFA Functional Classes
Food Additives -> ENZYME_PREPARATION;
Computed Properties
Molecular Weight:300.841
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:300.82607
Monoisotopic Mass:300.82607
Topological Polar Surface Area:23.8
Heavy Atom Count:5
Complexity:51.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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