Propylene glycol alginate

0.00000

440.15299094

DTXSID7044186

WHITE POWDER

0.00000

0.00000

1.2096

886.32°C (rough estimate)

1.7040

SOL IN DIL ORG ACIDS|READILY SOL IN HOT OR COLD WATER

Propylene glycol alginate is a stable material, although it will gradually become less soluble if stored at elevated temperatures for extended periods.
Propylene glycol alginate solutions are most stable at pH 3–6. In alkaline solutions, propylene glycol alginate is rapidly saponified. Alginate solutions are susceptible to microbial spoilage and should be sterilized or preserved with an antimicrobial preservative. However, sterilization processes may adversely affect the viscosity of propy

ODORLESS

VISCOSITY DEPENDENT ON TEMP, CONCN, MOLECULAR WT, & THE PRESENCE OF POLYVALENT METAL CATIONS; ACID STABLE|DECREASING VISCOSITY ON HEATING|HYDROPHILIC, LIPOPHILIC EMULSIFIER

MAY BE DEGRADED IF HELD @ HIGH TEMP FOR LONG PERIODS /ALGINATES/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Propylene glycol alginate is a food additive permitted for direct addition to food for human consumption, as long as 1) the quantity added to food does not exceed the amount reasonably required to accomplish its intended physical, nutritive, or other technical effect in food, and 2) when intended for use in or on food it is of appropriate food grade and is prepared and handled as a food ingredient.

WHO; Environ Health Criteria Number 32: Toxicological Evaluation of Certain Food Additives and Contaminants (1993)

LD50 Hamster oral 7000 mg/kg bw /From table/|LD50 Mouse oral 7800 mg/kg bw /From table/|LD50 Rabbit oral 7600 mg/kg bw /From table/|LD50 Rat oral 7200 mg/kg bw /From table/

WHEN PROPYLENEGLYCOL (14)C ALGINATE OR (14)C PROPYLENEGLYCOL ALGINATE...DOSED TO MICE, UNHYDROLYZED ESTER & ALGINATE RESIDUE...UNABSORBED FROM GI TRACT... HYDROLYZED PROPYLENEGLYCOL...ABSORBED...METABOLIZED & ELIMINATED... SINGLE DOSE OF 1 G/KG...EXCRETED IN FECES...IN 5 DAYS...|...AFTER A /SINGLE/ DOSE OF 5 G/KG, TRACES OF LABEL WERE STILL PRESENT IN RECTUM /AFTER 5 DAYS/.|ALGINATE PREPARED FROM LAMINARIA DIGITATA WAS UNABSORBED BY RATS FED AT A LEVEL OF 10% OF THEIR DAILY DIET. /ALGINATES/|Five g of propylene glycol alginate/kg bw (as a 10% aq soln), labeled with (14)C in the alginate moiety, or 1 g of propylene glycol alginate/kg bw (as a 5% aq soln), labeled with (14)C in the propylene glycol moiety, was admin as a single dose to mice (8/group) by gavage. Absorption, distribution and excretion of radioactivity were followed from 1 hr to 5 days after admin by whole body autoradiography. Some, but not all, of the label (labeled in the propylene glycol moiety) in a single dose of 1 g propylene glycol alginate/kg bw was absorbed. The unabsorbed portion was excreted in the feces within 3 days while the absorbed radioactivity was distributed rapidly over the whole body, was concn in the liver and was completely removed from all tissues in 3-4 days. These findings are consistent with the fate of absorbed radioactivity from labeled free propylene glycol and its metabolites. Five days after admin of 5 g propylene glycol alginate (labeled in the alginate moiety)/kg bw traces of radioactivity were still noted in the rectum. It was concluded that released propylene glycol was absorbed and metabolized by the usual pathways (to acetate, lactate or glycogen) and had disappeared completely from the body after 5 days. The alginate moiety and the unhydrolyzed propylene glycol alginate were not absorbed from the GI tract, but excreted in the feces ... .

In vitro hydrolysis studies with propylene glycol alginate in simulated gastric juice and simulated intestinal juice showed no hydrolysis in simulated gastric juice, while intestinal juice hydrolyzed 25% in 4 hr, 65% in 12 hr and 80% in 24 hr ... .

Results of chromosomal aberration assay using human WI-38 cells at up to 1.0 mg/ml were negative (without metabolic activation) /From table/|Fifty individuals known to be allergic to numerous substances were tested intradermally with various dilutions of propylene glycol alginate. Fifty other individuals without an allergic history or family history of allergy were used as controls. Eleven individuals showed slight to moderate skin reactions (8 in test group, 3 in control group). When five of those showing the greatest reactions (all in test group) were fed propylene glycol alginate three showed mild allergic reactions which were duplicated in repeated tests. Three control individuals, who showed very slight skin reactions, did not react to oral admin of propylene glycol alginate ... .|Five healthy male volunteers received 175 mg propylene glycol alginate/kg bw/day orally for 7 days, followed by 200 mg/kg bw/dy for a further 16 days. The daily doses were consumed in three measured portions at intervals each day. ... The treatment period was preceded by a 7 day initial control period. ... At day 3 of the initial control period, on the last day of the 23-day treatment period and on the last day of the 7 day recovery period the following parameters were examined: fasting blood glucose, plasma insulin, breath hydrogen concn, hematological parameters ... and biochemical parameters. ... Routine urinalysis was carried out during the initial control wk and during the third wk of treatment. Five day fecal collections were made during days 2-6 of the initial control period and during days 16-20 of the treatment period. ... No allergic reactions were observed. Propylene glycol alginate exerted no significant effects on fecal parameters. ... Fecal transit time was constant in 3 volunteers, increased in one and decreased in one. Fecal total and individual volatile fatty acids and total and individual bile acids did not show changes. Fecal total neutral sterols and cholesterol decreased in each volunteer. Hematological, biochemical and urinary parameters did not show significant changes ... .

PGAE

...PROPYLENE GLYCOL ALGINATES ARE USED @ 0.1-0.2% TO SUSPEND PULP IN FRUIT DRINKS.|PROPYLENE GLYCOL ALGINATE, @ LEVELS OF 0.15-0.25% IS...USED /IN ICE POPS TO IMPART SMOOTHNESS OF TEXTURE/...|DESIRABLE PROPERTIES...AS ICE CREAM STABILIZERS: 1. AIDS IN WHIPPING & PREVENTS ICE CRYSTAL FORMATION...2. PREVENTS STRUCTURAL BREAKDOWN DUE TO TEMP VARIATIONS... 3. GIVES A SMOOTH, EVEN MELTDOWN DURING EATING. /ALGINATES/|...AS STABILIZER PRODUCES THIN MIX THAT DOES NOT CLUMP OR GEL & IS MORE RESISTANT TO CALCIUM & OTHER SALTS...PROVIDING GOOD HEAT SHOCK PROTECTION TO FINISHED ICE CREAM.|A GELLING CARBOHYDRATE EXTRACTED FROM...SEAWEED (GIANT KELP, MACROCYSTIS PYRIFERA (L) AG, LESSONIACEAE) OR FROM HORSETAIL KELP (LAMINARIA DIGITATA (L) LAMOUR, LAMINARIACEAE) OR FROM SUGAR KELP (LAMINARIA SACCHARINA (L) LAMOUR). /ALGIN/

TEST FOR ALGINATES IN CHOCOLATE PRODUCTS. /ALGINATES/|ALGINATES IN MAYONNAISE, SALAD DRESSING, & FRENCH DRESSING: TEST FOR PRESENCE. /ALGINATES/|ALGINATES (25)--FIRST OFFICIAL ACTION. RESIDUE CONTAINS ALGINATES, GUMS, & GELATINS. /DETERMINED QUAL BY COLOR INDICATOR TEST/ DEEP PURPLE IS POSITIVE TEST FOR ALGINATES. /ALGINATES/

Food additives|Cosmetics -> Binding; Viscosity controlling