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Felbinac

Felbinac structure

CAS No:
5728-52-9
Formula:
C14H12O2
Chemical Name:
Felbinac
Synonyms:
[1,1′-Biphenyl]-4-acetic acid;4-Biphenylacetic acid;Acetic acid,(4-biphenylyl)-;p-Biphenylylacetic acid;4-Biphenylylacetic acid;p-Biphenylacetic acid;4-Carboxymethylbiphenyl;LY 61017;L 141;LJC 10141;Felbinac;Cl 83544;Traxam;4-Phenylphenylacetic acid;BPAA;Seltouch;NSC 16284;2-(Biphenyl-4-yl)acetic acid;([1,1′-Biphenyl]-4-yl)acetic acid;2-([1,1′-Biphenyl]-4-yl)acetic acid;(Biphenyl-4-yl)acetic acid;Felbion 35;2-(4-Phenylphenyl)acetic acid;154907-20-7
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

Felbinac is a potent non-steroidal anti-inflammatory agent, used to treat muscle inflammation and arthritis.

Biphenyl-4-ylacetic acid is a monocarboxylic acid in which one of the alpha-hydrogens is substituted by a biphenyl-4-yl group. An active metabolite of fenbufen, it is used as a topical medicine to treat muscle inflammation and arthritis. It has a role as a non-steroidal anti-inflammatory drug. It is a member of biphenyls and a monocarboxylic acid. It contains a biphenyl-4-yl group. It derives from an acetic acid.

Felbinac Basic Attributes

Molecular Weight：

212.24

Exact Mass：

212.24

BRN：

1211592

EC Number：

227-233-2

UNII：

94WNJ5U8L7

NSC Number：

760372|16284

DSSTox ID：

DTXSID0045389

ATC Code：

M02AA08|M - Musculo-skeletal system

HScode：

29163900

Characteristics

PSA：

37.3

XLogP3：

Appearance：

Beige Powder

Density：

1.2±0.1 g/cm3

Melting Point：

160.5 °C

Boiling Point：

389.8°C at 760 mmHg

Flash Point：

286.6±17.2 °C

Refractive Index：

1.596

Water Solubility：

DMSO: soluble 50mg/mL, clear, colorless to yellow

Storage Conditions：

Store below +30°C.

Toxicity：

Oral-rat LD50: 410 mg/kg; Oral-Mouse LD50: 675 mg/kg

Flammability characteristics：

Flammable; burning produces irritating fumes

Safety Information

Packing level：

III

Hazard category：

6.1

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

23/25-36/37/38-25-36/37/38/63-20/21/22

safety instructions：

26-36/37/39-45-37/39-28A-26/36/3745/60-20-36

RTECS Number：

DU8229050

Marks：

T,Xn

Storage features：

Ventilated, low temperature and dry; stored separately from food materials in warehouse

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P301 + P310-P305 + P351 + P338-P311

Hazard Statements：

H301 + H331-H315-H319-H335

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P311, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 97 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

MeSH Entry Terms：

3-biphenylylacetic acid

Felbinac Use and Manufacturing

Uses

Anti-inflammatory, analgesic drug.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:212.24
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:212.083729621
Monoisotopic Mass:212.083729621
Topological Polar Surface Area:37.3
Heavy Atom Count:16
Complexity:223
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Not clearly described

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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Registered Holders

Jiashan Jiasheng Pharmaceutical Co.,Ltd.

Japan
Active
DONGBANG FUTURE TECH & LIFE CO.,LTD.

Japan
Active
HANSEO CHEM CO.,LTD.

South Korea
Active

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Recommended Suppliers of Felbinac

Changzhou Xuanming Pharmaceutical Techno Contact Supplier

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5 YRS

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CAS No.: 5728-52-9

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Shandong Airuike Chemical Co., Ltd. Contact Supplier

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3 YRS

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Trader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE

Felbinac

CAS No.: 5728-52-9

Grade: Pharmaceutical grade

Content: 99%

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