GASTRIN RELEASING PEPTIDE, HUMAN
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GASTRIN RELEASING PEPTIDE, HUMAN
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CAS No:
93755-85-2
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Formula:
C130H204N38O31S2
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Chemical Name:
GASTRIN RELEASING PEPTIDE, HUMAN
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Synonyms:
GRP (HUMAN);GRP;H-VAL-PRO-LEU-PRO-ALA-GLY-GLY-GLY-THR-VAL-LEU-THR-LYS-MET-TYR-PRO-ARG-GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2;GASTRIN RELEASING AGENT, HUMAN;GASTRIN RELEASING PEPTIDE;GASTRIN RELEASING PEPTIDE, HUMAN;PubChem ID: 23185015;Gastrin releasing peptide, human, ≥97% (HPLC)
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CAS No:
Description
Gastrin-Releasing Peptide, human (GRP) belongs to the bombesin-like peptide family, and is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release.
Gut-brain peptides are widely conserved in vertebrates, GRP is a neuropeptide that modulates the autonomic system. It is an anorexigenic factor in the brain, regulates male sexual function at the spinal cord level, conveys the itch sensation, and is also involved in many autonomic regulations in the brain. The expression of GRP is also a specific tumor marker for small cell lung cancer. It has the GXHWAVGHLM amide (X=N or S) sequence at its C-terminus.
GRP (gastrin releasing peptide) is the mammalian homolog of bombesin (BBS) and functions as a mitogen for multiple cancers, such as neuroblastoma. It is a ligand for GRPR (GRP receptor) and is expressed in a subtype of peptidergic dorsal root ganglion neurons.
GASTRIN RELEASING PEPTIDE, HUMAN Basic Attributes
2859.38
2857.499512
DTXSID00631217
White to off-white
GASTRIN RELEASING PEPTIDE, HUMAN Use and Manufacturing
GRP (gastrin releasing peptide) has been used for absorption/neutralization of anti-GRP antibody prior to the tyramide signal amplification (TSA) procedure.
Computed Properties
Molecular Weight:2859.4
XLogP3:-2.2
Hydrogen Bond Donor Count:36
Hydrogen Bond Acceptor Count:38
Rotatable Bond Count:86
Exact Mass:2858.5029690
Monoisotopic Mass:2857.4996142
Topological Polar Surface Area:1110
Heavy Atom Count:201
Complexity:6470
Undefined Atom Stereocenter Count:24
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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