Isovaline

1.4) Compound F1 (13.8 g, 95.0 mmol)And sodium hydroxide (7.6g, 190.08mmol) was added to ethanol in sequenceIn a mixed solution (200 ml) with water (1:1 by volume), Heated back to reflux for 4 hours.The solution was adjusted to pH = 7 with hydrochloric acid at a concentration of 2M, and the solvent was dried.The reaction is dissolved in a small amount of water and then purified by a strong acid cation exchange resin type 732.Product G1 (10 g, 90percent) was obtained as a white solid.117 g (1 mol) of L-isoproline was suspended in 1500 mL of methanol, and while stirring well, 179 g (1.5 mol) of thionyl chloride was slowly added to the suspension.After the addition, the temperature was refluxed for 3 h. The resulting reaction mixture was cooled to room temperature and filtered.The filter cake was washed several times with methanol.The filtrate and the methanol wash were combined and concentrated under reduced pressure. Add toluene to the residue obtained, stirmix.The toluene was removed to give the desired product L-isoproline methyl ester hydrochloride 159 g (yield: 95%).

Molecular Weight:153.61
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:153.0556563
Monoisotopic Mass:153.0556563
Topological Polar Surface Area:63.3
Heavy Atom Count:9
Complexity:103
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes