Tanshinone I
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Tanshinone I
structure -
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CAS No:
568-73-0
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Formula:
C18H12O3
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Chemical Name:
Tanshinone I
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Synonyms:
Phenanthro[1,2-b]furan-10,11-dione,1,6-dimethyl-;1,6-Dimethylphenanthro[1,2-b]furan-10,11-dione;Tanshinone I;Tanshinon I;Tanshinone A
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CAS No:
Description
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 (IC50=11 μM) and rabbit recombinant cPLA2 (IC50=82 μM).
Tanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent.
Characteristics
47.3
3.7
red
1.3±0.1 g/cm3
230-232 °C @ Solvent: Methanol
498°C at 760 mmHg
245.9±15.6 °C
1.676
DMSO: soluble 1mg/mL
2-8°C
Drug Information
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (See all compounds classified as Anti-Infective Agents.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. (See all compounds classified as Antineoplastic Agents, Phytogenic.)|Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)|Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)
tanshinone
Computed Properties
Molecular Weight:276.3
XLogP3:3.7
Hydrogen Bond Acceptor Count:3
Exact Mass:276.078644241
Monoisotopic Mass:276.078644241
Topological Polar Surface Area:47.3
Heavy Atom Count:21
Complexity:471
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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