Tetraethyltin

234.95

234.95

209-906-2

31RE6NA75O

22315

3384|2788

DTXSID9022073

Colorless liquid

2931909018

0

3.51480

Tetraethyltin is a colorless liquid. Used as biocides, bactericides, fungicides and insecticides; preservatives for wood, textile, paper, and leather. Not registered as a pesticide in the U.S. (EPA, 1998)

1.199 g/cm³ @ Temp: 20 °C

-112 °C

181 °C @ Press: 760 Torr

128 °F

n20/D 1.473(lit.)

Insoluble in water. soluble in alcohol and ether;soluble in organic solvents.

Refrigerator (+4°C) + Poison room

1.2 mm Hg @ 20 deg C

Explodes on rapid heating.

... /Tetraethyltin/ tends to ignite in air.

It may ignite in air.

Organometallics

When heated to decomposition, TETRAETHYLTIN emits acrid smoke and fumes. (nonspecific -- Organic Tin Compounds) Avoid strong oxidizers. [EPA, 1998].

42.4 kJ/mol

II

6.1

UN 3384 6.1/PG 1

2

26/27/28-50/53

26-27-28-45-60-61

WH8625000

T+,N

P260-P264-P273-P280-P284-P301 + P310

H226-H300 + H310 + H330-H410

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

When heated to decomposition, it emits acrid smoke and fumes. (Non-Specific -- Organic Tin Compounds) Avoid strong oxidizers. (EPA, 1998)|Flammable - 2nd degree

|Danger|H226 (90.7%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P262, P264, P270, P271, P273, P280, P284, P301+P310, P302+P350, P303+P361+P353, P304+P340, P310, P320, P321, P322, P330, P361, P363, P370+P378, P391, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 43 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

This is a liquid organotin pesticide. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. This material may burn but does not ignite readily. Extinguish small fires with dry chemical, carbon dioxide, water spray or foam. For large fires, use water spray, fog, or foam. (EPA, 1998)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: See ERG Table 1 - Initial Isolation and Protective Action Distances on the UN/NA 3384 datasheet. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

This is a liquid organotin pesticide. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Large spills: dike far ahead of spill for later disposal. (EPA, 1998)

For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998)

... /Tetraethyltin/ tends to ignite in air.

Explodes on rapid heating.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

External contact ... with the eyes or with the skin would presumably cause much irritation and injury since trialkyl tin compounds commonly have vesicant and lacrimatory effects.

Releases of CERCLA hazardous substances are subject to the release reporting requirement of CERCLA section 103, codified at 40 CFR part 302, in addition to the requirements of 40 CFR part 355. Tetraethyl tin is an extremely hazardous substance (EHS) subject to reporting requirements when stored in amounts in excess of its threshold planning quantity (TPQ) of 100 lbs. Extremely hazardous substances that are solids are subject to either of two threshold planning quantities ... The lower quantity applies only if the solid exists in powdered for and has a particle size less than 100 microns; or is handled in solution or in molten form; or meets the criteria for a National Fire Protection Association (NFPA) rating of 2, 3 or 4 for reactivity. If the solid does not meet any of these criteria, it is subject to the upper ... threshold planning quantity ... .

LD50 Rat oral 9 to 16 mg/kg body wt|MLD Mouse intraperitoneal 32 mg/kg|LD50 Rabbit oral 7 mg/kg|LD50 Guinea pig oral 37 mg/kg

Tetraethyl tin's production and use as one of the tetraorganotin chemical intermediates for the tri-, di-, and monoorganotin compounds(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 760(SRC), determined from a structure estimation method(2), indicates that tetraethyl tin is expected to have low mobility in soil(SRC). Volatilization of tetraethyl tin from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.63 atm-cu m/mole(SRC), using a fragment constant estimation method(3). The potential for volatilization of tetraethyl tin from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.2 mm Hg(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Tetraethyl tin may be susceptible to biodegradation in soil based upon possible biodegradability of butyltin compounds such as tri-, di- and monobutyltin species(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 760(SRC), determined from a structure estimation method(2), indicates that tetraethyl tin is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.63 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2 hrs and 6 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 77,000(SRC), from an estimated log Kow of 5.4(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Tetraethyl tin may be susceptible to biodegradation in water based upon possible biodegradability of butyltin compounds such as tri-, di- and monobutyltin species(5).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetraethyl tin, which has a vapor pressure of 1.2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetraethyl tin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 hrs(SRC), calculated from its estimated rate constant of 3.8X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Tetraethyl tin may absorb ultraviolet light >290 nm and may be susceptible to direct photolysis based upon the absorption behavior of tri-, di-, and monobutyltin compounds(4).

The rate constant for the vapor-phase reaction of tetraethyl tin with photochemically-produced hydroxyl radicals has been estimated as 3.8X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 10 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tetraethyl tin is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2).|Tetraethyl tin may absorb ultraviolet light >290 nm and may be susceptible to direct photolysis based upon the absorption behavior of tri-, di-, and monobutyltin compounds(1). Tetraethyl tin may react with free radicals since certain compounds containing the Sn-C bond are good radical traps(2).

An estimated BCF of 77,000 was calculated for tetraethyl tin(SRC), using an estimated log Kow of 5.44(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for tetraethyl tin can be estimated to be 760(SRC). According to a classification scheme(2), this estimated Koc value suggests that tetraethyl tin is expected to have low mobility in soil.

The Henry's Law constant for tetraethyl tin is estimated as 0.63 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that tetraethyl tin is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 2 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 6 days(SRC). Tetraethyl tin's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). However, adsoprtion may attenuate this process. The potential for volatilization of tetraethyl tin from dry soil surfaces may exist(SRC) based upon a vapor pressure of 1.2 mm Hg(3).

Occupational exposure to tetraethyl tin may occur through inhalation and dermal contact with this compound at workplaces where tetraethyl tin is produced or used. (SRC)

The dealkylation of tetraethyltin to triethyltin ... is fast. ...|The metabolism of tetraethyltin to triethyltin assures that the relative distribution and chemical forms of tin are similar after treatment with tetraethyl- or triethyltin.|Tetraethyltin was rapidly metabolized by isolated rat liver microsome preparations, and in rats after iv injection, to form triethyltin derivatives. Also, the triethyltin products were shown to be metabolized further to diethyltin derivatives in an in vitro system.|The reduced form of nicotinamide-adenine dinucleotide phosphate and oxygen dependent microsomal metabolism of the di-, tri- and tetra-ethyl-substituted derivatives of germanium, tin, and lead gave rise to ethylene as a major product and ethane as a minor product in rats. These reactions were catalyzed by liver microsomal cytochrome p450-dependent monooxygenase. Since formation of ethane and ethylene was differentially inhibited by anaerobiosis, results suggested that a large portion of the ethane produced was derived by a reductive mechanism. Triethyltin bromide in the absence and presence of the reduced form of nicotinamide-adenine dinucleotide phosphate converted cytochrome p450 into cytochrome p420 and affected the function of monooxygenase in vitro. Tetraethyltin caused the reduced form of nicotinamide-adenine dinucleotide phosphate and the time-dependent formation of cytochrome p420, suggesting that tetraethyltin was converted into triethyltin salts in significant concentrations. The order of potency in formation of cytochrome p420 was closely paralleled by the ability of tin derivatives to induce microsomal lipid peroxidation in vitro.|The metabolism and toxicity of some ethyl-substituted organotin compounds in isolated rat hepatocytes were studied. Tetra- and triethyltin derivatives were metabolized by isolated rat hepatocytes to yield ethane and ethylene. Hydrocarbon formation from tetraethyltin was larger than that obtained with triethyltin bromide and ethylene was the major product (95%) of tetraethyltin metabolism. At a triethyltin salt concentration of 100 uM, the major product formed by cells from untreated rats was ethane. Pretreatment in vivo by phenobarbital resulted in a marked increase in the overall rate of hydrocarbon production and a change in ethylene ratio; ethylene was the predominant metabolite produced. 5,6-Benzoflavone pretreatment in vivo resulted in a small depression in overall hydrocarbon production. No metabolites of diethyltin dichloride (100 uM) by isolated rat heptocytes was detected. Triethyltin bromide (100 uM) was a potent inhibitor of phase 1 (oxidation) and phase 2 (conjugation) metabolism of biphenyl in isolated hepatocytes from phenobarbital-pretreated rats: diethyltin dichloride affected particularly the phase 1 metabolism of the aromatic hydrocarbon. Triethyl- and diethyltin salts reduced O2 consumption and ATP levels in these cells. The triethyl derivative was more effective. Tetraethyltin was not apparently toxic to hepatocytes. Trypan blue dye exclusion and lactate dehydrogenase loss by the cell isolated from phenobarbital-pretreated rats indicated that triethyltin bromide was more toxic than diethyltin dichloride. The diethyl derivative was more potent in stimulating lipid peroxidation as indicated by the formation of thiobarbituric acid-reactive products than triethyltin.

Toxic hazard rating is high for oral, intravenous, intraperitoneal administration. This material causes swelling of the brain and spinal cord. (EPA, 1998)

Signs and Symptoms of Tetraethyltin Exposure: Signs and symptoms of acute exposure to tetraethyltin may include nausea, vomiting, cramping, pneumoconiosis, occasionally bronchitis, liver failure, peritonitis (inflammation of the abdominal lining) and biliary tract damage. Other symptoms may include headache, visual defects, skin burns or dermatitis, unsteadiness, and swelling of the brain and spinal cord. Emergency Life-Support Procedures: Acute exposure to tetraethyltin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination. Inhalation Exposure: 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to tetraethyltin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 4. Transport to a health care facility. Dermal/Eye Exposure: 1. Remove victims from exposure. Emergency personnel should avoid self-exposure to tetraethyltin. 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 3. Remove and isolate contaminated clothing as soon as possible. 4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes. 5. Wash exposed skin areas thoroughly with soap and water. 6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 7. Transport to a health care facility. Ingestion Exposure: 1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support. 2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures. 3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of tetraethyltin is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step 4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of tetraethyltin may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step 4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal. 4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water. 5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults. 6. Transport to a health care facility. (EPA, 1998)

tetraethyl tin

Stannane, tetraethyl-: ACTIVE

Fire Hazards -> Flammable - 2nd degree