Tetrasodium EDTA

380.17000

380.01800

616-941-0

MP1J8420LU

1688

DTXSID3026350

White powder

S - Sensory organs

2922499990

167.00000

5.01 (calculated)

White; Crystalline Powder

6.9 g/cm3

>300 °C

614.2ºC at 760 mmHg

325.2ºC

H2O: 0.1 g/mL, clear, colorless

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

pH of 1% soln: 11.3

Amorphous

>200 °C

Dust explosion possible if in powder or granular form, mixed with air.

2

R36/38

S26-S37/39

AH5075000

Xi

Separated from strong oxidants and strong bases.

Stable. Incompatible with strong oxidizing agents.

P261, P264, P270, P271, P280, P301+P312, P304+P340, P305+P351+P338, P310, P312, P330, P403+P233, P405, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Incompatible with strong acids, nitrates, oxidizers. Can solubilize metals.|Reacts with most divalent and trivalent metallic ions forming soluble metal chelates.

Indirect food additives: Substances for use as components of coatings. Resinous and polymeric coatings. Tetrasodium EDTA is included on this list.

Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P310, P330, and P501|H302 (99.95%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P304+P312, P304+P340, P305+P351+P338, P310, P312, P330, and P501|Aggregated GHS information provided by 4211 companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P261, P264, P270, P271, P280, P301+P312, P304+P340, P305+P351+P338, P310, P312, P330, P403+P233, P405, and P501|Warning|P260, P264, P270, P280, P301+P312, P305+P351+P338, P309+P311, P330, P337+P313, P405, and P501

Nonflammable. Use extinguisher appropriate to other burning material. ...

... Remove all ignition sources. Collect powdered material in the convenient and safe manner and deposit in sealed containers. Ventilate area after clean-up is complete. ...

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Both edetic acid and Na4EDTA are mild skin irritants, but comparatively potent eye irritants.

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water.

Separated from strong oxidants and strong bases.

A harmful concentration of airborne particles can be reached quickly when dispersed.

The substance is irritating to the eyes.

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust.

PREVENT DISPERSION OF DUST!

Use local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

Tetracycline-HCl absorption in man, given concomitantly with tetra-Na EDTA and milk, showed inhibitory effect of milk counteracted by simultaneous ingestion of EDTA.|Cortisol reduced degree of vascular damage to adrenalectomized rat irrigated with Na4-EDTA salt if administered within 1-6 hr prior to EDTA, no protection if delayed until 15 min prior to EDTA.

LD50 Mouse ip 330 mg/kg|LD50 Rat ip >2.0 g/kg|LD50 Rat ip 4000 mg/kg bw

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of tetrasodium EDTA is 1000 or greater; the data may be greatly underestimated(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 1,388,281 workers (611,582 of these were female) were potentially exposed to tetrasodium EDTA in the US(1).

Tetrasodium edetate used in dust as sequestering agent should not be applied to eye unless first neutralized, because it forms solution sufficiently alkaline to be injurious to eye.|/Investigators/ examined the efficacy of tetrasodium EDTA in eradicating biofilms derived from salivary inocula or pure cultures of Candida albicans on discs of polymethyl methacrylate (PMMA) denture base or on toothbrushes that had been used normally for 4-8 weeks. Its efficiency in virus neutralization was also determined. Overnight (16 hr) treatment with 4% (w/v) tetrasodium EDTA solution reduced salivary and C. albicans biofilm viable counts by > or =99%. Biofilm removal was confirmed using confocal laser scanning microscopy. Presence/absence of sucrose during biofilm formation had no effect on killing efficacy. Prolonged treatment of PMMA with tetrasodium EDTA did not influence subsequent formation of C. albicans biofilms or affect surface roughness of the PMMA, but it reduced subsequent biofilm formation from a salivary inoculum. Infectivities of herpes simplex virus and polio virus suspensions were reduced by >99.99% by treatment for 1 and 2 hr, respectively. Tetrasodium EDTA solution efficiently disinfected toothbrushes and PMMA discs, with the detachment of biofilms, and rapidly neutralized both nonenveloped and enveloped viruses. Dentures and toothbrushes become contaminated by bacterial biofilms and by viruses. There is a need for disinfection methods that are rapidly effective, cost-effective, nontoxic and easily implemented. These studies indicate that tetrasodium EDTA solution has disinfection applications in the oral care field.|Central venous catheter (CVC)-related bloodstream infections (BSIs) are known to increase rates of morbidity and mortality in both inpatients and outpatients, including hematology-oncology patients and those undergoing hemodialysis or home infusion therapy. Biofilm-associated organisms on the lumens of these catheters have reduced susceptibility to antimicrobial chemotherapy. This study tested the efficacy of tetrasodium EDTA as a catheter lock solution on biofilms of several clinically relevant microorganisms. Biofilms of Staphylococcus epidermidis, methicillin-resistant S. aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Candida albicans were grown to levels of approximately 1 x 10+5 colony-forming units (CFU) cm(-1) on CVC segments in a model system, then subjected to the tetrasodium EDTA lock treatment. Comparisons of biofilms before and after exposure to the 40-mg mL(-1) tetrasodium EDTA lock for 21 hours showed that the biofilm viable cell counts of all organisms tested were significantly reduced (P < 0.05) after exposure to the treatment. Antimicrobial lock treatment using 40 mg mL(-1) of tetrasodium EDTA for at least 21 hours could significantly reduce or potentially eradicate CVC-associated biofilms of clinically relevant microorganisms.|Exptl use: trilon b had significant therapeutic effect when injected iv at 50 mg/kg into rabbits and 150-175 mg/kg ip into mice poisoned with lithium chloride.|...Tetrasodium edta is effective for treating lime burns of cornea and /as chelating agent/ for treating hypercalcemia patients by removing blood calcium.

/Investigators/ reported that Tetrasodium EDTA could contain an unspecified amount of the starting material, formaldehyde.

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Give ... calcium gluconate ... or ... calcium chloride slowly iv. Repeat as needed every 5 to 10 minutes.|/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

/HUMAN EXPOSURE STUDIES/ Tetrasodium edetate used in dust as sequestering agent should not be applied to eye unless first neutralized, because it forms solution sufficiently alkaline to be injurious to eye.|/SIGNS AND SYMPTOMS/ Rapid intravenous administration of Na2EDTA causes hypocalcemic tetany. However, a slow infusion (15 mg per minute) administered to a normal individual elicits no symptoms of hypocalcemia because of the ready availability of extracirculatory stores of calcium.|/CASE REPORTS/ A 75-year-old man being treated for several malignant epithelial tumors was prescribed a sunscreen Uriage SPF50+ cream. After 10 months of using the product, the patient presented with eczematous areas where the sunscreen had been applied (face, neck and back of hands). Patch testing was performed with standard series of GEIDAC (Spanish Contact Dermatitis and Cutaneous Allergy Research Group), sunscreen series (Chemotechnique Diagnostics, Malmo, Sweden) and the Uriage SPF50+ cream. After 4 days, a positive reaction was observed to the cream (++). The manufacturer supplied the individual ingredients of their product. Out of the 24 components provided, only tetrasodium ethylenediaminetetraacetic acid (EDTA) 0.2% aqua was positive and it was negative in five controls subjects. ... In our patient, there was a close relation between the application of the sunscreen and the appearance of eczema. Positive patch test was only obtained with 0.2% aqua tetrasodium EDTA as a component of the sunscreen, whereas ethylenediamine was negative. His eczema resolved once the sunscreen ceased to be used. He is now using a mineral-based product without EDTA.|/OTHER TOXICITY INFORMATION/ .../Edetic acid/ and many of its salts bind metal cations tightly and so render them essentially innocuous. /EDTA and its salts/|For more Human Toxicity Excerpts (Complete) data for TETRASODIUM EDTA (6 total), please visit the HSDB record page.

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Cough. Sore throat.

Redness.

Redness. Pain.

The cosmetic-grade material contains a minimum of 99.0% Tetrasodium EDTA as Na4EDTA.2H2O|Anhydrous or dihydrate.

All other basic organic chemical manufacturing|Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:4): ACTIVE|A number of salts of EDTA are available with uses identical or similar to the acid. The USP salts are called edetates (calcium disodium, disodium edetates); others are usually abbreviated to EDTA (tetrasodium, trisodium EDTA). Other salts, known chiefly under trademark names, are the sodium ferric, dihydrogen ferrous and a range of disodium salts with magnesium, divalent cobalt, manganese, copper, zinc, and nickel.|Historical data (data submitted to the FDA in 1984) indicated that EDTA and Tetrasodium EDTA were used typically at concentrations up to 1%, but one formulation each contained concentrations of 25%.|It has been estimated that daily human consumption of EDTA salts are 1.5 x 10-4 for Tetrasodium EDTA.|Odor and taste evaluations indicated that 1% dip of tetrasodium EDTA increased shelf-life of fish from 5-9 to 10 days and significantly decreased development of trimethylamine and volatile, basic nitrogen compounds.|For more General Manufacturing Information (Complete) data for TETRASODIUM EDTA (6 total), please visit the HSDB record page.

Cosmetics -> Chelating