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(2-Chloroethoxy)benzene

(2-Chloroethoxy)benzene structure

CAS No:
622-86-6
Formula:
C8H9ClO
Chemical Name:
(2-Chloroethoxy)benzene
Synonyms:
Benzene,(2-chloroethoxy)-;Phenetole,β-chloro-;(2-Chloroethoxy)benzene;2-Phenoxyethyl chloride;β-Chlorophenetole;1-Phenoxy-2-chloroethane;2-Chloroethyl phenyl ether;1-Chloro-2-phenoxyethane;NSC 1073
Categories:
Pharmaceutical Intermediates > Antineoplastics

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Description

Pale Yellow Oil

(2-Chloroethoxy)benzene Basic Attributes

Molecular Weight：

156.61

Exact Mass：

156.61

BRN：

971048

EC Number：

210-757-0

NSC Number：

1073

DSSTox ID：

DTXSID6060761

HScode：

2909309090

Characteristics

PSA：

9.2

XLogP3：

2.4

Appearance：

Pale yellow oil

Density：

1.132 g/cm³ @ Temp: 20 °C

Melting Point：

28 °C

Boiling Point：

218.5 °C

Flash Point：

213 °F

Refractive Index：

1.512

Peroxide Forming Chemical：

(2-Chloroethoxy)benzene|D: Other compounds that may form peroxides|Kelly

Safety Information

Transport codes：

UN 3265

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (91.84%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 49 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

(2-Chloroethoxy)benzene Use and Manufacturing

Methods of Manufacturing

Derived from the reaction of phenol and dichloroethane. Add phenol, sodium hydroxide solution and water into the autoclave, stir evenly to form a sodium phenate solution, add dichloroethane, heat up to 130°C in 4h, pressure 0.75-0.88MPa, and react for 3h. Cool to 45°C, add lye to wash, stand for layering, add hydrochloric acid to the water layer to recover excess phenol. The oil layer is flowed with water to pH 7, and the dichloroethane is evaporated to obtain the crude product, which is then rectified to obtain the product.

Uses

Used for the synthesis of naphazodone and other raw materials

Manufacturing Info：

Benzene, (2-chloroethoxy)-: INACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:156.61
XLogP3:2.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:156.0341926
Monoisotopic Mass:156.0341926
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:79.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

1,2-Dichloroethane

Phenol

Benzyltrimethylammonium chloride

Dimethyl sulfoxide

Recommended Suppliers of (2-Chloroethoxy)benzene

Shaanxi Dideu Medichem Co. Ltd Contact Supplier

CN
5 YRS

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Manufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive

High Quality 99% Purity of 2-Phenoxyethyl chloride CAS NO 622-86-6 ISO 9001:2005 REACH Verified Producer

CAS No.: 622-86-6

Grade: Industrial Grade

Content: 99%

Inquiry
Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

2-Phenoxyethyl chloride 622-86-6

CAS No.: 622-86-6

Grade: Pharmaceutical Grade

Content: 99%

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