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Chrysosplenetin

Chrysosplenetin structure

CAS No:
603-56-5
Formula:
C19H18O8
Chemical Name:
Chrysosplenetin
Synonyms:
4H-1-Benzopyran-4-one,5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-;Chrysosplenetin;Flavone,4′,5-dihydroxy-3,3′,6,7-tetramethoxy-;5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one;Chrysosplenol B;5,4′-Dihydroxy-3,6,7,3′-tetramethoxyflavone;Quercetagetin 3,6,7,3′-tetramethyl ether;3,6,7,3′-Tetra-O-methylquercetagetin;EMD 20940;4′,5-Dihydroxy-3,3′,6,7-tetramethoxyflavone;Polycladin;Jaceidin 7-O-methyl ether;Chrysosptertin B;69234-29-3
Categories:
Natural Products > Flavonoids

Description

Chrysosplenetin is one of the polymethoxylated flavonoids in Artemisia annua L. (Compositae) and other several Chinese herbs. Chrysosplenetin inhibits P-gp activity and reverses the up-regulated P-gp and MDR1 levels induced by artemisinin (ART). Chrysosplenetin significantly augments the rat plasma level and anti-malarial efficacy of ART, partially due to the uncompetitive inhibition effect of Chrysosplenetin on rat CYP3A[1].

Chrysosplenetin is a tetramethoxyflavone that is the 3,6,7,3'-tetramethyl ether derivative of quercetagetin. It has a role as an antiviral agent and a plant metabolite. It is a tetramethoxyflavone and a dihydroxyflavone. It derives from a quercetagetin.

Chrysosplenetin Basic Attributes

Molecular Weight：

374.34142

Exact Mass：

374.34

UNII：

9AA5Z8PMYE

Characteristics

PSA：

107.59000

XLogP3：

2.26

Density：

1.4±0.1 g/cm3

Melting Point：

203-205 °C

Boiling Point：

615.8±55.0 °C at 760 mmHg

Flash Point：

222.7±25.0 °C

Refractive Index：

1.640

Drug Information

MeSH Entry Terms：

chrysosplenetin

Chrysosplenetin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:374.3
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:5
Exact Mass:374.10016753
Monoisotopic Mass:374.10016753
Topological Polar Surface Area:104
Heavy Atom Count:27
Complexity:576
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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chrysoplenetin

CAS No.: 603-56-5

Content: 99.00%

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Guide of Chrysosplenetin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
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