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Dansyl chloride

Dansyl chloride structure

CAS No:
605-65-2
Formula:
C12H12ClNO2S
Chemical Name:
Dansyl chloride
Synonyms:
1-Naphthalenesulfonyl chloride,5-(dimethylamino)-;5-(Dimethylamino)-1-naphthalenesulfonyl chloride;Dansyl chloride;1-(Dimethylamino)-5-naphthalenesulfonyl chloride;DNS chloride;5-(N,N-Dimethylamino)-1-naphthalenesulfonyl chloride;DNS-Cl;NSC 83616;8-Dimethylamino-1-naphthalenesulfonyl chloride;558479-38-2
Categories:
Chemical Reagents > Organic Reagents

Description

Dansyl chloride is a reagent that reacts with primary amino groups in both aliphatic and aromatic amines to produce stable blue- or blue-green-fluorescent sulfonamide adducts. Dansyl chloride is widely used to modify amino acids; specifically, protein sequencing and amino acid analysis. It can also be used to label hydroxyl and carboxylic acid functional groups.

Dansyl chloride is an aminonaphthalene and a sulfonic acid derivative.

Dansyl chloride Basic Attributes

Molecular Weight：

269.75

Exact Mass：

269.75

BRN：

2217205

EC Number：

210-092-6

UNII：

QMU9166TJ4

NSC Number：

83616

DSSTox ID：

DTXSID2060543

HScode：

29214980

Characteristics

PSA：

45.8

XLogP3：

3.5

Appearance：

yellow to orange powder and chunks

Density：

1.4±0.1 g/cm3

Melting Point：

70 °C

Boiling Point：

371.3°C at 760 mmHg

Flash Point：

178.4±22.3 °C

Refractive Index：

1.636

Water Solubility：

soluble in dimethyl fluoride, acetone, chloroform, pyridine, benzene and dioxane. Insoluble in water.acetone: 50 mg/mL

Storage Conditions：

2-8°C

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

UN 3261 8/PG 2

wgk germany：

hazard class code：

safety instructions：

26-36/37/39-45-3

RTECS Number：

QK3688000

Marks：

Precautionary statement(s)：

P280-P305 + P351 + P338-P310

Hazard Statements：

H314

GHS Classification：

|Danger|H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]|P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501|Aggregated GHS information provided by 52 companies from 6 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

5-(dimethylamino)naphthalene-1-sulfonylchloride

Dansyl chloride Use and Manufacturing

Uses

In fluorescent labelling, column chromatography, HPLC.

Manufacturing Info：

1-Naphthalenesulfonyl chloride, 5-(dimethylamino)-: ACTIVE

Computed Properties

Molecular Weight:269.75
XLogP3:3.5
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:269.0277275
Monoisotopic Mass:269.0277275
Topological Polar Surface Area:45.8
Heavy Atom Count:17
Complexity:363
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethyl acetate

Sodium bicarbonate

Hydrochloric acid

Dimethyl sulfate

PETROLEUM ETHER

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