2,6-Dinitro-p-cresol

198.13300

198.13

210-203-8

L572BVH6NF

33870

DTXSID9027239

Yellow needles from ether or petroleum ether|Light yellow crystalline solid

111.87000

2.56340

Yellow-orange flakes.

1.55 g/cm3

85 °C

270.4ºC at 760 mmHg

117.7ºC

1.639

Soluble in alcohol, ether, benzene

Store in a cool, dry place. Store in a tightly closed container.

2.2X10-5 mm Hg at 25 deg C (est)

5.30e-08 atm-m3/mole|Henry's Law constant = 5.30X10-8 atm-cu m/mole at 20 °C

pKa = 4.23 at 25 °C

Hydroxyl radical reaction rate constant = 3X10-13 cu cm/molecule-sec at 25 °C (est)

II

6.1(a)

UN 2811 6.1/PG 2

3

R23/24/25;R33

S26-S45-S36/37

GO9800000

T:Toxic;

APPEAR TO BE STABLE IN ACID SOLN, BUT ARE SUSCEPTIBLE TO DECOMPOSITION BY UV RADIATION IN ALKALINE SOLN. /DINITROPHENOLS/

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

H300

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

U.S. Dept Health & Human Services/Agency for Toxic Substances Disease Registry; Toxicological Profile for Dinitrocresols (1995) NTIS # PB/95/264321

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

/NIOSH APPROVED RESPIRATOR/; GOGGLES OR FACE SHIELD; PROTECTIVE CLOTHING; RUBBER GLOVES. /DINITROCRESOLS/

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Dust and vapor of dinitrophenol have been reported to be irritating to mucous membrane in industrial exposure ... . /Dinitrophenol/|CONTACT WITH EYES CAUSES IRRITATION. /DINITROCRESOLS/

LD50 Mouse ip 24.8 mg/kg

4-Methyl-2,6-dinitrophenol's production and use as a chemical intermediate for dyes and pharmaceuticals(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 750(SRC), determined from a structure estimation method(2) indicates that 4-methyl-2,6-dinitrophenol is expected to have low mobility in soil(SRC). However, the pKa of 4-methyl-2,6-dinitrophenol is 4.23(3), which indicates that this compound will exist partially as an anion in moist soil surfaces and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Field studies have shown that the anionic form of the analogous compound, 2-methyl-4,6-dinitrophenol, is more mobile in soil(5); therefore, the anionic form of 4-methyl-2,6-dinitrophenol may have high to moderate mobility in soil(SRC). Volatilization of 4-methyl-2,6-dinitrophenol from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 5.3X10-8 atm-cu m/mole(6). 4-Methyl-2,6-dinitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its estimated vapor pressure of 2.2X10-5 mm Hg at 25 °C(SRC) determined from a fragment constant method(2). Dinitroaromatic compounds absorb UV light strongly above 290 nm and are susceptible to direct photolysis in sunlight(7); therefore, 4-methyl-2,6-dinitrophenol is expected to be susceptible to photodegradation on surfaces exposed to sunlight(SRC). By analogy to 2-methyl-4,6-dinitrophenol, which disappears from soil within a few weeks to 2 months when under normal field application rates(8), biodegradation may be an important environmental fate process in soil(SRC). In soil, the nitro groups are reduced to amino groups(9).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 750(SRC), determined from a structure estimation method(2) indicates that 4-methyl-2,6-dinitrophenol may adsorb to suspended solids and sediment in water(SRC). However, the pKa of 4-methyl-2,6-dinitrophenol is 4.23(3), which indicates that this compound will exist partially as an anion in water and the anionic form of this type of compound has been observed to absorb less strongly than its neutral form(4). Volatilization from water surfaces is not expected(5) based upon a estimated Henry's Law constant of 5.3X10-8 atm-cu m/mole at 20 °C(6). According to a classification scheme(7), an estimated BCF value of 15(SRC) from its estimated log Kow of 2.27(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. 4-Methyl-2,6-dinitrophenol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(5). Nitrophenols and dinitroaromatic compounds exhibit strong absorption of UV light at wavelengths greater than 290 nm(8,9), suggesting that 4-methyl-2,6-dinitrophenol is susceptible to direct photolysis in the environment(SRC). The half-life for the photolysis of the analogous compound 2-methyl-4,6-dinitrophenol in water has been reported as approximately 253 hours at 20 °C(10). Biodegradation half-lives of analogous 2-methyl-4,6-dinitrophenol in water have been reported as 3-5 weeks at 20 °C(10), suggesting biodegradation of 4-methyl-2,6-dinitrophenol may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 4-methyl-2,6-dinitrophenol, which has an estimated vapor pressure of 2.2X10-5 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 4-methyl-2,6-dinitrophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 53 days(SRC) from its estimated rate constant of 3X10-13 cu cm/molecule-sec at 25 °C(2). Particulate-phase 4-methyl-2,6-dinitrophenol may be removed from the air by wet and dry deposition(SRC). Nitrophenols and dinitroaromatic compounds exhibit strong absorption of UV light at wavelengths greater than 290 nm(3,4), suggesting that 4-methyl-2,6-dinitrophenol is susceptible to direct photolysis in the environment(SRC).

The rate constant for the vapor-phase reaction of 4-methyl-2,6-dinitrophenol with photochemically-produced hydroxyl radicals has been estimated as 3X10-13 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 53 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 4-Methyl-2,6-dinitrophenol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). Nitrophenols and dinitroaromatic compounds exhibit strong absorption of UV light at wavelengths greater than 290 nm(3,4), suggesting that 4-methyl-2,6-dinitrophenol is susceptible to direct photolysis in the environment(SRC). The half-life for the photolysis of the analogous compound 2-methyl-4,6-dinitrophenol in water has been reported as approximately 253 hours at 20 °C(5). [

An estimated BCF of 15 was calculated for 4-methyl-2,6-dinitrophenol(SRC), using an estimated log Kow of 2.27(1) and a regression-derived equation(1). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 4-methyl-2,6-dinitrophenol can be estimated to be 750(SRC). According to a classification scheme(2), this estimated Koc value suggests that 4-methyl-2,6-dinitrophenol is expected to have low mobility in soil. However, the pKa of 4-methyl-2,6-dinitrophenol is 4.23(3), which indicates that this compound will exist primarily as an anion in moist soil surfaces and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Field studies have shown that the anionic form of the analogous compound 2-methyl-4,6-dinitrophenol is more mobile in soil(5); therefore, the anionic form of 4-methyl-2,6-dinitrophenol may have high to moderate mobility in soil(SRC).

The Henry's Law constant for 4-methyl-2,6-dinitrophenol has been measured as 5.3X10-8 atm-cu m/mole at 20 °C(1). This Henry's Law constant indicates that 4-methyl-2,6-dinitrophenol is expected to be essentially nonvolatile from water surfaces(2). 4-methyl-2,6-dinitrophenol's Henry's Law constant indicates that volatilization from moist soil surfaces is not expected occur(SRC). 4-Methyl-2,6-dinitrophenol is not expected to volatilize from dry soil surfaces(SRC) based upon its estimated vapor pressure of 2.2X10-5 mm Hg at 25 °C(SRC) determined from a fragment constant method(3).

GROUNDWATER: 4-Methyl-2,6-dinitrophenol was detected at concentrations of 2.5-27 ug/L in groundwater at a former munitions plant in Saxony, Germany(1).

Occupational exposure to 4-methyl-2,6-dinitrophenol may occur through dermal contact with this compound at workplaces where 4-methyl-2,6-dinitrophenol is produced or used. (SRC)

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Dinitrophenol and Related Compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . Rapid body cooling may be necessary in case of hyperthermia. Salicylates are contraindicated. /Dinitrophenol and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of 0.9% saline (NS) or lactated Ringer's (LR) /SRP: "To keep open", minimal flow rate/. For dehydration and hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Dinitrophenol and Related Compounds/

/SIGNS AND SYMPTOMS/SYMPTOMATOLOGY: MARKED FATIGUE, TREMENDOUS THIRST, PROFUSE SWEATING, FLUSHING OF FACE. NAUSEA, VOMITING, ABDOMINAL PAIN, & OCCASIONALLY DIARRHEA. RESTLESSNESS, ANXIETY, EXCITEMENT, OCCASIONALLY LEADING TO CONVULSIONS. /DINITROPHENOL/|/SIGNS AND SYMPTOMS/SYMPTOMATOLOGY: RISE IN BODY TEMP...ROUGHLY PROPORTIONAL TO TOXIC DOSE, MAY CULMINATE IN SEVERE HYPERPYREXIA... TACHYCARDIA, HYPERPNEA, DYSPNEA, CYANOSIS, &...MUSCLE CRAMPS. LOSS OF CONSCIOUSNESS, CESSATION OF BREATHING, & DEATH. /DINITROPHENOL/|/SIGNS AND SYMPTOMS/SYMPTOMATOLOGY: LATE COMPLICATIONS: A. DECR URINE OUTPUT WITH ALBUMINURIA, CASTS, PIGMENTS, SOMETIMES BLOOD CELLS, DUE TO TOXIC NEPHRITIS. B. JAUNDICE & TENDERNESS IN LIVER REGION DUE TO TOXIC HEPATITIS. /DINITROPHENOL/|/SIGNS AND SYMPTOMS/SYMPTOMATOLOGY: OCCASIONAL HYPERSENSITIVITY REACTIONS AFTER REPEATED EXPOSURES (OR IN CHRONIC POISONING) INCLUDE AGRANULOCYTIC ANGINA, SKIN RASHES, PERIPHERAL NEURITIS, & LATE CATARACT FORMATION. /DINITROPHENOL/|/SIGNS AND SYMPTOMS/SYMPTOMS FOLLOWING EXPOSURE: VERY HIGH FEVER IS PROMINENT SIGN OF INTOXICATION FOLLOWING ABSORPTION OF TOXIC DOSE OF DINITRO-O-CRESOL. INHALATION OF DUST MAY CAUSE SAME SYMPTOMS AS INGESTION. INGESTION CAUSES A FEELING OF WELL-BEING, PROFUSE SWEATING, YELLOW URINE, INCR BASAL METABOLISM, MARKED THIRST, VOMITING, CONVULSIONS, COMA, & DEATH. CONTACT WITH EYES CAUSES IRRITATION. CONTACT WITH SKIN CAUSES LOCAL NECROSIS & DANGEROUS SYSTEMIC EFFECTS. NOTE: ...FURTHER CONTACT SHOULD BE AVOIDED IF /BLOOD/ LEVEL EXCEEDS 20 UG/G. /DINITROCRESOLS/

2,6-dinitro-p-cresol

Grade: Presscake (36-43% active 2,6-DNCP)

Phenol, 4-methyl-2,6-dinitro-: ACTIVE