Thioacetamide

75.13

75.13

506006

200-541-4

075T165X8M

0579

2120

3077

DTXSID9021340

C44454

Crystals from benzene|Colorless leaflets|Yellow tablets|CRYSTALS FROM ALC, PLATES FROM ETHER

29309070

58.1

-0.46/-0.36

Off-white to slightly beige Liquid

1.1±0.1 g/cm3

113-114 °C

45.3±23.0 °C at 760 mmHg

see Notes

1.522

H2O: 16.3 g/100 mL (25 ºC)

Store at RT.

MLD orally in rats: 200 mg/kg (Ambrose)

Slight odor of mercaptans

pKa= 13.40

Slightly water soluble.

Amides and Imides

THIOACETAMIDE reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases (NTP, 1992).

2811

3

45-22-36/38-52/53

53-45-61-99

AC8925000

T

Separated from food and feedstuffs.

Stability Incompatible with water, mineral acids.

P201-P273-P305 + P351 + P338-P308 + P313

H302-H315-H319-H350-H412

At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|Thioacetamide is a potential candidate for incineration. Recommended incineration types: Rotary kiln with a temperature range 820 to 1600 °C and a residence time of hours; Fluidized bed with a temperature range 840 to 1800 °C and a residence time of several seconds or longer.|PRECAUTIONS FOR "CARCINOGENS": There is no universal method of disposal that has been proved satisfactory for all carcinogenic compounds & specific methods of chem destruction ... published have not been tested on all kinds of carcinogen-containing waste. ... summary of avail methods & recommendations ... /given/ must be treated as guide only. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Incineration may be only feasible method for disposal of contaminated laboratory waste from biological expt. However, not all incinerators are suitable for this purpose. The most efficient type ... is probably the gas-fired type, in which a first-stage combustion with a less than stoichiometric air:fuel ratio is followed by a second stage with excess air. Some ... are designed to accept ... aqueous & organic-solvent solutions, otherwise it is necessary ... to absorb soln onto suitable combustible material, such as sawdust. Alternatively, chem destruction may be used, esp when small quantities ... are to be destroyed in laboratory. /Chemical Carcinogens/|For more Disposal Methods (Complete) data for THIOACETAMIDE (7 total), please visit the HSDB record page.

FORMS COMPD & SULFIDES WITH SALTS OF HEAVY METALS; HYDROLYZED BY ACIDS OR BASES, FORMING ACETIC ACID, AMMONIA, NITROGEN & HYDROGEN SULFIDE

REVIEW:[NEAL RA, HALPERT J; TOXICOLOGY OF THIONO-SULFUR COMPOUNDS; ANNU REV PHARMACOL TOXICOL 22: 321 (1982)]|National Toxicology Program. Eleventh Report on Carcinogens (2005). The Report on Carcinogens is an informational scientific and public health document that identifies and discusses substances (including agents, mixtures, or exposure circumstances) that may pose a carcinogenic hazard to human health. Thioacetamide (62-55-5) is listed as reasonably anticipated to be a human carcinogen.[Available from, as of July 31, 2009: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/s172thio.pdf]

Flash point data on this compound are not available; it is probably combustible. (NTP, 1992)|Combustible.

|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P273, P280, P281, P301+P312, P302+P352, P305+P351+P338, P308+P313, P321, P330, P332+P313, P337+P313, P362, P405, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 73 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P201, P202, P260, P264, P270, P281, P301+P312, P308+P313, P309+P311, P314, P330, P405, and P501

Fires involving this chemical should be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. (NTP, 1992)|Use water spray, powder, alcohol-resistant foam, carbon dioxide.

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)|PRECAUTIONS FOR "CARCINOGENS": ... Dispensers of liq detergent /should be available./ ... Safety pipettes should be used for all pipetting. ... In animal laboratory, personnel should ... wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. ... Gowns ... /should be/ of distinctive color, this is a reminder that they are not to be worn outside the laboratory. /Chemical Carcinogens/

PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

VENTILATION CONTROL: BASIC VENTILATION METHODS ARE LOCAL EXHAUST VENTILATION & DILUTION OR GENERAL VENTILATION.|PRECAUTIONS FOR "CARCINOGENS": Smoking, drinking, eating, storage of food or of food & beverage containers or utensils, & the application of cosmetics should be prohibited in any laboratory. All personnel should remove gloves, if worn, after completion of procedures in which carcinogens have been used. They should ... wash ... hands, preferably using dispensers of liq detergent, & rinse ... thoroughly. Consideration should be given to appropriate methods for cleaning the skin, depending on nature of the contaminant. No standard procedure can be recommended, but the use of organic solvents should be avoided. Safety pipettes should be used for all pipetting. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": In animal laboratory, personnel should remove their outdoor clothes & wear protective suits (preferably disposable, one-piece & close-fitting at ankles & wrists), gloves, hair covering & overshoes. ... Clothing should be changed daily but ... discarded immediately if obvious contamination occurs ... /also,/ workers should shower immediately. In chemical laboratory, gloves & gowns should always be worn ... however, gloves should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, & disposable plastic aprons might provide addnl protection. If gowns are of distinctive color, this is a reminder that they should not be worn outside of lab. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": ... Operations connected with synth & purification ... should be carried out under well-ventilated hood. Analytical procedures ... should be carried out with care & vapors evolved during ... procedures should be removed. ... Expert advice should be obtained before existing fume cupboards are used ... & when new fume cupboards are installed. It is desirable that there be means for decreasing the rate of air extraction, so that carcinogenic powders can be handled without ... powder being blown around the hood. Glove boxes should be kept under negative air pressure. Air changes should be adequate, so that concn of vapors of volatile carcinogens will not occur. /Chemical Carcinogens/|For more Preventive Measures (Complete) data for THIOACETAMIDE (10 total), please visit the HSDB record page.

PRECAUTIONS FOR "CARCINOGENS": Procurement ... of unduly large amt ... should be avoided. To avoid spilling, carcinogens should be transported in securely sealed glass bottles or ampoules, which should themselves be placed inside strong screw-cap or snap-top container that will not open when dropped & will resist attack from the carcinogen. Both bottle & the outside container should be appropriately labelled. ... National post offices, railway companies, road haulage companies & airlines have regulations governing transport of hazardous materials. These authorities should be consulted before ... material is shipped. /Chemical Carcinogens/|PRECAUTIONS FOR "CARCINOGENS": When no regulations exist, the following procedure must be adopted. The carcinogen should be enclosed in a securely sealed, watertight container (primary container), which should be enclosed in a second, unbreakable, leakproof container that will withstand chem attack from the carcinogen (secondary container). The space between primary & secondary container should be filled with absorbent material, which would withstand chem attack from the carcinogen & is sufficient to absorb the entire contents of the primary container in the event of breakage or leakage. Each secondary container should then be enclosed in a strong outer box. The space between the secondary container & the outer box should be filled with an appropriate quantity of shock-absorbent material. Sender should use fastest & most secure form of transport & notify recipient of its departure. If parcel is not received when expected, carrier should be informed so that immediate effort can be made to find it. Traffic schedules should be consulted to avoid ... arrival on weekend or holiday ... /Chemical Carcinogens/

Personal protection: complete protective clothing including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

Separated from food and feedstuffs.

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

The substance may have effects on the liver. This may result in tissue lesions. This substance is possibly carcinogenic to humans.

NO open flames.

PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!

Use local exhaust.

Protective gloves.

Wear safety spectacles.

U218; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 10 lb or 4.54 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

U218; As stipulated in 40 CFR 261.33, when thioacetamide, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5).

DISTRIBUTION OF PU /SRP: plutonium/ IN RATS WAS INFLUENCED BY ORAL ADMIN OF THIOACETAMIDE (300 MG/KG). RATS INJECTED IP WITH PLUTONIUM CITRATE RETAINED 71.5 & 23.6% OF RECOVERED ACTIVITY IN THE CARCASS & LIVER, RESPECTIVELY, WHEREAS RATS WHICH HAD BEEN TREATED WITH THIOACETAMIDE 24 HR PREVIOUSLY CONTAINED 35.8 & 59.5% OF THE PU IN THE CARCASS & LIVER RESPECTIVELY.|PHENOBARBITAL PRETREATMENT POTENTIATED HEPATIC NECROSIS PRODUCED BY THIOACETAMIDE.|ADRENALECTOMY PROTECTED RATS AGAINST THE HEPATOTOXIC ACTION OF THIOACETAMIDE INJECTED IP AT 200 MG/KG BW. THIS PROTECTIVE EFFECT COULD BE REVERSED BY HYDROCORTISONE GIVEN TWICE DAILY INTRAPERITONEALLY AT 0.5 TO 2.5 MG/RAT.|STROPHANTHIN-G PROTECTED RATS AGAINST LIVER NECROSIS CAUSED BY THIOACETAMIDE.|For more Interactions (Complete) data for THIOACETAMIDE (10 total), please visit the HSDB record page.

LD50 Rat oral 301 mg/kg|LD50 Mouse ip 300 mg/kg

Thioacetamide has not been reported to occur in nature.

Thioacetamide's production and use as a substitute for hydrogen sulfide in the laboratory(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 17(SRC), determined from an log Kow of -0.26(2) and a regression-derived equation(3), indicates that thioacetamide is expected to have very high mobility in soil(SRC). Volatilization of thioacetamide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.4X10-6 atm-cu m/mole(SRC), using a fragment constant estimation method(4). The potential for volatilization of thioacetamide from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 15 mm Hg(SRC), determined from a fragment constant method(5). Thioacetamide was not biodegraded by activated sludge after 5 days(6), and therefore may be resistant to biodegradation in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 17(SRC), determined from an log Kow of -0.26(2) and a regression-derived equation(3), indicates that thioacetamide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 6.4X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3 days and 39 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Thioacetamide was not biodegraded by activated sludge after 5 days(7), and therefore may be resistant to biodegradation in aqueous systems(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), thioacetamide, which has an estimated vapor pressure of 15 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere(SRC). Vapor-phase thioacetamide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hours(SRC), calculated from its rate constant of 21X10-12 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3).

The rate constant for the vapor-phase reaction of thioacetamide with photochemically-produced hydroxyl radicals has been estimated as 21X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Thioacetamide is expected to be stable in aqueous solutions(2), however, it hydrolyzes in acids and bases(3). Chemical hydrolysis is not expected to be important since amides hydrolyze very slowly at environmental conditions(4). Thioacetamide is not expected to directly photolyze due to the lack of absorption in the environmental UV spectrum (>290 nm)(SRC).

An estimated BCF of 3 was calculated for thioacetamide(SRC), using a log Kow of -0.26(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

6.03 L/kg|The Koc of thioacetamide is estimated as 17(SRC), using a log Kow of -0.26(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that thioacetamide is expected to have very high mobility in soil(SRC).

The Henry's Law constant for thioacetamide is estimated as 6.4X10-6 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that thioacetamide is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 80 hrs(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 39 days(SRC). Thioacetamide's Henry's Law constant(1) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of thioacetamide from dry soil surfaces may exist(SRC) based upon an estimated vapor pressure of 15.2 mm Hg(SRC), determined from a fragment constant method(3).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 786 workers (592 of these are female) are potentially exposed to thioacetamide in the US(1). Occupational exposure to thioacetamide may occur through inhalation and dermal contact with this compound at workplaces where thioacetamide is produced or used(SRC).

WHEN 5 MG (3)H-THIOACETAMIDE WERE ADMIN ORALLY IN DIET TO MALE ALBINO RATS... RADIOACTIVITY WAS FOUND IN ALL ORGANS EXAMINED (LIVER, KIDNEY & ADRENAL GLAND) & WAS HIGHEST IN LIVER.|WHOLE-BODY AUTORADIOGRAPHY SHOWED THAT AN IV DOSE OF ANTITHYROID AGENT, (35)S-THIOACETAMIDE, WAS TAKEN UP IN LIVER, KIDNEYS (MEDULLA), HEART MUSCLE, HARDERIAN GLANDS, SPLEEN, LYMPH NODES, & GI TRACT OF RATS. ABOUT 80% WAS EXCRETED IN 24-HR URINE.|THE DISTRIBUTION OF LABELED THIOACETAMIDE WAS STUDIED AS A FUNCTION OF TIME IN LIVER, KIDNEYS, PLASMA, AND MUSCLE OF RATS. THE DEVELOPMENT OF CENTRILOBULAR HEPATIC NECROSIS WAS FIRST OBSERVED 6 HOURS AFTER PEAK PLASMA LEVELS OF THIOACETAMIDE-S-OXIDE WERE OBTAINED (9 HOURS AFTER ADMINISTRATION OF THIOACETAMIDE).

...THIOACETAMIDE IS METABOLIZED IN VIVO TO ACETAMIDE WHICH IS ITSELF CARCINOGENIC...ACETAMIDE IS THEN HYDROLYZED TO ACETATE...|THIOACETAMIDE, A PRE- OR PROCARCINOGEN, MUST UNDERGO BIOCHEMICAL METABOLIC ACTIVATION BY HOST. /FROM TABLE/|HEPATOTOXICITY OF THIOACETAMIDE MAY BE MEDIATED BY ITS METAB TO THIOACETAMIDE SULFINE WHICH IN TURN, IS METABOLIZED TO AN ULTIMATE TOXIC METABOLITE.|THIOACETAMIDE IS OXIDIZED TO THIOACETAMIDE S-OXIDE BY RAT LIVER MICROSOMES & BY A MIXED-FUNCTION OXIDASE SYSTEM.|For more Metabolism/Metabolites (Complete) data for THIOACETAMIDE (9 total), please visit the HSDB record page.

Multiple injections of thioacetamide ... decrease the synthesis of cytochrome p450b and the amounts of its translatable mRNA.|A factor was isolated from /thioacetamide-induced/ fibrogenic rat liver which stimulates collagen synthesis in cultured fibrolblasts without affecting their rate of proliferation.|Altered transport of nuclear RNA sequences is an early response to carcinogens. Nuclear envelopes were isolated and assayed for nucleoside triphosphatase (NTPase) activity, on the premise that this enzymatic activity participates in RNA transport. A common feature of the action of ... thioacetamide ... at low doses without significant toxicity, was to increase nuclear envelopes NTPase activity and to increase RNA transport, as assessed by the appearance of rapiidly labeled RNA in the cytoplasm and by in vitro assay. The increases in NTPase were specific for the nuclear envelope fraction, and early toxic effects of higher doses initially masked the increases. The induced increases in nuclear envelope NTPase were long-lived. In contrast, increases in nuclear envelope NTPase were observed only during the regenerative phase of carbon tetrachloride intoxication; the CCl4-induced increase was short-lived and returned promptly to control levels. These changes in NTPase activity were not associated with parallel changes in phosphorylation/dephosphorylation of nuclear envelope proteins. Increases in nuclear envelope NTPase and alterations in RNA transport, without attendant nuclear replication, may relate to altered nuclear RNA restriction. This change in a regulatory phenomenon may make these cells more susceptible to further modification, potentially playing a role in the initiation phase of carcinogenesis.

SYMPTOMS: The symptoms following exposure to this compound may include skin and eye irritation, liver damage, fatigue, nausea, eczema, central nervous system depression, acidosis, vomiting, respiratory depression, hypotension, unconsciousness, tremors, convulsions, anorexia and conjunctivitis. ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits very toxic fumes. It may also cause skin and eye irritation. This compound is toxic by ingestion and inhalation. IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. (NTP, 1992)|Carcinogens

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: If any of your personnel should inhale this substance you should remove them immediately to open air. If symptoms develop, seek medical attention. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 m1/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . Cover skin burns with dry sterile dressings after decontamination ... . /Sulfur and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Early intubation at the first sign of upper airway obstruction may be necessary. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Treat seizures with diazepam ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Sulfur and related compounds/

...SEVERAL PEOPLE DEVELOPED DEGENERATIVE CHANGES IN LIVER FROM DRINKING JUICE OF ORANGES WHICH HAD BEEN IMMERSED FOR 2-5 SEC IN 5% SOLN OF THIOACETAMIDE TO PREVENT GROWTH OF BLUE & GREEN MOLDS.

Thiacetamid

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Ethanethioamide: ACTIVE

POTENTIOMETRIC METHOD USING SULFIDE ION-SELECTIVE MEMBRANE ELECTRODE FOLLOWING TITRATION OF THIOACETAMIDE WITH SILVER NITRATE... PAPAY MK ET AL; POTENTIOMETRIC STUDIES ON THIOACETAMIDE BY MEANS OF A SULFIDE ION-SELECTIVE MEMBRANE ELECTRODE; ANALYT CHIM ACTA 64: 409 (1973).|SIMPLE AND ACCURATE TITRIMETRIC METHODS FOR THE DETERMINATION OF THIOACETAMIDE IN AQUEOUS AND NONAQUEOUS SOLUTIONS WERE BASED ON ITS RAPID OXIDATION WITH CHLORAMINE-1 AT ROOM TEMPERATURE.|EPA Method 1625-BNW: Semivolatile Organic Compounds by Isotope Dilution GC/MS. This method is applicable to the determination of base/neutral toxic organic pollutants in water and sludges containing <1% solids. Detection limit = 99 ug/l.|EPA Method 1625-S: Semivolatile Organic Compounds by Isotope Dilution GC/MS. This method is applicable to the determination of toxic organic pollutants in soils and municipal sludges. Detection limit unspecified.

Health Hazards -> Carcinogens