2-Methylimidazole

Solid. Soluble in water, ethanol, slightly soluble in cold benzene.

• CAS No：

  693-98-1

• Molecular Formula ：

  C4H6N2

• Molecular Mass ：

  82.1

• Exact Mass ：

  82.053101

• PSA ：

  28.7

• LogP ：

  0.2

• EINECS ：

  211-765-7

• InChIKeys ：

  LXBGSDVWAMZHDD-UHFFFAOYSA-N

• H-bond Acceptor ：

  1

• H-bond Donor ：

  1

• SP3 ：

  0.25

• RBN ：

  0

• Appearance ：

  White to light yellow Crystalline Powder

• Density ：

  1.1±0.1 g/cm3

• Melting Point ：

  142-143 °C(lit.)

• Bolling Point ：

  267-268 °C(lit.)

• Flash Point ：

  155 °C

• Refractive Index ：

  1.523

• Solubility ：

  soluble in water and ethanol.

• Storage Condition ：

  2-8°C

• Vapor Pressure ：

  <1 mm Hg ( 0 °C)

• BRN ：

  1368

• Packing Group ：

  III

• Hazard Class ：

  8

• HS Code ：

  29332990

• UN No. ：

  UN 3259 8/PG 2

• WGK_Germany ：

  2

• Risk Code ：

  22-34

• Safety Instructions ：

  26-36/37/39-45-25

• RTECS No. ：

  NI7175000

• Dangerous Mark ：

  C

• P Code ：

  P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313

• Hazard Statements ：

  H302-H314-H351-H360

• Hazard Note ：

  Harmful/Corrosive

• Toxicity ：

  LD50 orally in Rabbit: 1500 mg/kg

2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-stream tobacco smoke.

Derived from the elimination of 2-methylimidazoline dehydrogenation. 2-Methylimidazoline was heated and melted (melting point 107℃), active nickel was carefully added, and the temperature was raised to 200-210℃ for 2h. Reduce the temperature to below 150 ℃, add water to dissolve, filter while hot, separate the active nickel, concentrate the filtrate to a temperature above 140 ℃, and discharge to cool to obtain 2-methylimidazole. Using this method to produce products with a purity of ≥98%, 1t of product consumes 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. The preferred method is to use glyoxal and aldehyde as raw materials.