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Home > Encyclopedia > 2-Methylimidazole

2-Methylimidazole

2-Methylimidazole structure
  • CAS No:

    693-98-1

  • Formula:

    C4H6N2

  • Synonyms:

    2MI;2MZ;2MZ-H;2MZ-PW;NSC 21394;Curezol 2MZ;Denka CN 25;Actiron 2MI;Epicure MI 2;Epikure MI 2

  • Categories:

    API  >  Feed Additive

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Description

Solid. Soluble in water, ethanol, slightly soluble in cold benzene.

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Basic Attributes

  • 693-98-1

  • C4H6N2

  • 82.1

  • 82.053101

  • 28.7

  • 0.2

  • 211-765-7

  • LXBGSDVWAMZHDD-UHFFFAOYSA-N

  • 1

  • 1

  • 0.25

  • 0

Characteristics

  • White to light yellow Crystalline Powder

  • 1.1±0.1 g/cm3

  • 142-143 °C(lit.)

  • 267-268 °C(lit.)

  • 155 °C

  • 1.523

  • soluble in water and ethanol.

  • 2-8°C

  • <1 mm Hg ( 0 °C)

  • 1368

Safety Information

  • III

  • 8

  • 29332990

  • UN 3259 8/PG 2

  • 2

  • 22-34

  • 26-36/37/39-45-25

  • NI7175000

  • C

  • P201-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P308 + P313

  • H302-H314-H351-H360

  • Harmful/Corrosive

  • LD50 orally in Rabbit: 1500 mg/kg

Usage

2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-stream tobacco smoke.

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Production Methods

Derived from the elimination of 2-methylimidazoline dehydrogenation. 2-Methylimidazoline was heated and melted (melting point 107℃), active nickel was carefully added, and the temperature was raised to 200-210℃ for 2h. Reduce the temperature to below 150 ℃, add water to dissolve, filter while hot, separate the active nickel, concentrate the filtrate to a temperature above 140 ℃, and discharge to cool to obtain 2-methylimidazole. Using this method to produce products with a purity of ≥98%, 1t of product consumes 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. The preferred method is to use glyoxal and aldehyde as raw materials.

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