Arsanilic acid

217.05

217.05

1102334

202-674-3

UDX9AKS7GM

759173|2023

3082

DTXSID8035138

C29883

Needles from water or alcohol|Crystalline powder

29310095

83.6

-1.28

white crystalline powder

1.9571 g/cm³ @ Temp: 10 °C

232 °C

528.5±52.0 °C at 760 mmHg

273.4±30.7 °C

SLIGHTLY soluble in cold water

p-Arsanilic acid should be kept stored in a tightly closed container in a cool, dry, wellventilated area. It should be kept away from incompatible materials, dust generation, excess heat, and strong oxidants.

Oral-rat LD50: 1000 mg/kg; Abdominal cavity-mouse LD50: 500 mg/kg

Flammable; heated to decompose toxic arsenide and nitrogen oxide gas; decompose toxic fumes in case of acid

Practically odorless

133.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

III

6.1

UN 3465 6.1/PG 3

3

23/25-50/53

20/21-28-45-60-61-28A

CF7875000

T,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable at room temperature in closed containers under normal storage and handling conditions.

P261-P273-P301 + P310-P311-P501

H301 + H331-H410

...ON CONTACT WITH ACID OR ACID FUMES, IT EMITS HIGHLY TOXIC FUMES OF /ARSENIC & NITROGEN OXIDE/.

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P304+P340, P311, P321, P330, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

YIELDS FLAMMABLE VAPORS ON HEATING ABOVE MELTING POINT.

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Arsanilic acid is included on this list.|(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/|The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

moderately

... The effects of cadmium (50 mg/kg diet) & lead (200 mg/kg) on the toxicity of arsenic administered to rats as sodium arsenate or arsanilic acid in the food (50 mg As/kg diet) /was examined/. The efficiency of food utilization was more reduced by the combination of arsenic & cadmium than by each metal alone. The combination of arsenic & cadmium also caused a greater decr in serum alkaline phosphatase levels than either metal alone. Additive effects of arsenic & lead in coproporphyrin excretion were also noted. Increased uroporphyrin excretion in rats was reported ..., when lead cadmium & arsenic were combined compared with excretion levels following exposure to arsenic alone.

LD50 Rat oral >1000 mg/kg|LD50 Mouse ip 248 mg/kg|LD50 Mouse iv 100 mg/kg

VET: /IN/ COCCIDIOSIS CONTROL...LEVELS OF LESS THAN 90 G/TON HAVE QUESTIONABLE VALUE FOR BROILERS &, ALTHOUGH NOT APPROVED, INDICATIONS ARE THAT LEVELS CLOSE TO 360 G/TON (0.04% OF RATION) PRODUCE MAXIMUM RESPONSE IN BROILERS.|VET: USE: ...CONTROLS BLOODY ENTERITIS (VIBRIOS, ETC) IN SWINE, CAN COUNTERACT TOXIC EFFECTS OF SELENIUM IN CATTLE & SWINE.|(VET): ANTIPROTOZOAN ADDITIVE FOR ANIMAL FEEDS; VET MEDICINAL FOR SWINE|(VET): GROWTH PROMOTANT, TO IMPROVE FEED EFFICIENCY

PIGS FED WITH ARSANILIC ACID HAD HIGH LEVELS (OVER 20 PPM) OF ARSENIC IN LIVER & KIDNEY CORTEX AFTER FEW DAYS OF ILLNESS, LEVELS THEN DECR ALTHOUGH ADMIN OF DRUG CONTINUED...|Experiments with pigs given a diet containing 0.01% arsanilic acid for 31 days showed a rapid decr in the tissue levels of arsenic during the first days after the feeding of arsanilic acid was discontinued. The livers contained arsenic concns of 1.5-2 mg/kg on the 31st day of feeding & about 0.2 mg/kg on the 7th day after the removal of the arsanilic acid from the diet.|Rats fed protein from swine liver containing 24.4 mg arsenic/kg protein as arsanilic acid, at a level of 300 g/kg diet for 14 days, eliminated almost all of the arsenic within 7 days of the end of the feeding period. The amount of arsenic excreted in the urine was one third of the amount of arsenic eliminated in the feces during this period.|...FED ARSANILIC ACID TO SWINE...5-10% OF AS EXCRETED IN FECES WAS ARSANILIC ACID. A RAPID DECR IN TISSUE AS & EXCRETION FOLLOWING REMOVAL OF ADDITIVE WAS FOUND. @ HIGH RATES, AS ALSO APPEARED IN URINE, BUT NOT AS ARSANILIC ACID.|For more Absorption, Distribution and Excretion (Complete) data for ARSANILIC ACID (8 total), please visit the HSDB record page.

Carcinogens

ARSANILIC ACID...CONSUMPTION DOES NOT GIVE RISE TO POISONING...IN MAN...|SIMILAR TO OTHER /ANTISYPHILITIC/ DERIVATIVES OF ARSANILIC ACID, /ACETARSOL/... CAUSED OPTIC NEURITIS & OPTIC ATROPHY...GREATEST DANGER...IV INJECTION... VISION FIELDS CONTRACTED & VISION...POOR IN DIM ILLUMINATION. IN ONE...CASE, RETROLOBULAR NEURITIS WITH CENTRAL SCOTOMA FOR COLORS...AFTER 20 DAYS TREATMENT... /ACETARSOL/|HIGHLY TOXIC.|Complaints of keratosis were roughly two-fold higher than unexposed controls in female packaging workers exposed to arsanilic acid at an avg concn of 0.05 mg As/m3 and in male manufacturing workers exposed to an avg concn of 0.13 mg As/m3 in a chemical factory ... .

4 Aminobenzenearsonic Acid

CONTAINS 34.5% ARSENIC.

Arsonic acid, As-(4-aminophenyl)-: INACTIVE|IMPROVES GROWTH RATE, FEED EFFICIENCY, PIGMENTATION, FEATHERING, & EGG PRODN IN CHICKENS & TURKEYS. IMPROVES GROWTH RATE & FEED EFFICIENCY...IN SWINE.|WARNING: DO NOT ADMIN TO BIRDS LAYING EGGS FOR HUMAN CONSUMPTION. DISCONTINUE USE @ LEAST 5 DAYS BEFORE SLAUGHTERING POULTRY OR ANIMALS TO PERMIT ELIMINATION OF DRUG FROM EDIBLE TISSUES.|...ARSANILIC ACID...INCORPORATED IN ANIMAL FEEDING-STUFFS @ RATE OF 50-100 PPM...FED TO PIGS & POULTRY @ LEVELS UP TO 150 PPM, ADMIN BEING DISCONTINUED 10 DAYS BEFORE SLAUGHTER.|...ARSANILIC ACID...SUGGESTED...TO BE OF POSSIBLE VALUE ON THE FARM. @ LEVELS OF...0.02%.../ARSANILIC ACID/ PROTECTED AGAINST UP TO 10 PPM OF SELENITE SELENIUM IN PIG WITHOUT GIVING RISE TO TOXIC EFFECTS DUE TO.../ITS/ ARSENIC CONTENT...

AOAC Method 964.28 p-Aminobenzoic Acid in Feeds. Sprotphotometirc Method. Lab method for differentiation of p-aminobenzoic acid, arsanilic acid, and sulfaquinoxaline.|AOAC Method 954.17. Arsanilic acid in feeds. Spectrophotometric method.

Health Hazards -> Carcinogens