2-Bromo-N,N-dimethylbenzenamine
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2-Bromo-N,N-dimethylbenzenamine
structure -
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CAS No:
698-00-0
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Formula:
C8H10BrN
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Chemical Name:
2-Bromo-N,N-dimethylbenzenamine
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Synonyms:
Benzenamine,2-bromo-N,N-dimethyl-;Aniline,o-bromo-N,N-dimethyl-;2-Bromo-N,N-dimethylbenzenamine;o-Bromo-N,N-dimethylaniline;2-Bromo-N,N-dimethylaniline;2-(Dimethylamino)bromobenzene;2-(Dimethylamino)phenyl bromide;NSC 33816;N,N-Dimethyl-2-bromoaniline;2-Dimethylamino-1-bromobenzene;2-(N,N-Dimethylamino)bromobenzene;1-Bromo-2-dimethylaminobenzene;(2-Bromophenyl)dimethylamine
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CAS No:
Safety Information
UN2810 - class 6.1 - PG 3 - EHS - Toxic, liquids, organic, n.o.s., HI: all
3
R36/37/38
S26-S36
Xi
P261-P273-P280-P301 + P310-P305 + P351 + P338-P311
H301 + H311 + H331-H319-H351-H373-H410
|Danger|H301+H311+H331 (86.36%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]|P201, P202, P260, P261, P264, P270, P271, P273, P280, P281, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P311, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Bromo-N,N-dimethylbenzenamine Use and Manufacturing
In a 250 mL round bottom flask, 4.0 g (23.3 mmol) of 2-bromoaniline, 16.1 g (116.5 mmol) of anhydrous potassium carbonate, 7.3 mL (116.5 mmol) of methyl iodide (CH3I) and 50 mL of acetonitrile (MeCN) were added and heated. Up to 70 ° C.After stirring at 70 ° C for 18 h, the reaction mixture was cooled to room temperature.It was extracted with 100 mL of deionized water and 100 mL of diethyl ether. After the organic phase is separated, The aqueous phase was washed with 3 x 50 mL diethyl ether. The combined organic phase was washed with 5 x 50 mL of saturated brine.The organic phase was then dried over anhydrous magnesium sulfate. Next, the volatile component in the organic phase was distilled off under reduced pressure to give a crude material. The crude product was separated by silica gel column chromatography to yield 2.7 g of pale yellow oily liquid.The eluent was diethyl ether / hexane (5 / 95 v / v), yield 69percent. Relevant characterization data is consistent with the literature reported above.
suzuki reaction
Computed Properties
Molecular Weight:200.08
XLogP3:2.7
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:198.99966
Monoisotopic Mass:198.99966
Topological Polar Surface Area:3.2
Heavy Atom Count:10
Complexity:103
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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