1-Ethoxy-4-iodobenzene

Off-white low melting solid

233.50 g (1.06mol) 4-Iodo-phenol and 42.45 g (1.06 mol) NaOH was placed into a dry mortar andwell milled into powder, and then the mixture was transfered to 1000 mLround-bottom flask equipped with a magnetic stirrer. 300 mL of bromoethane, 15 mL of N, N-dimethylformamide and a catalytic amount of CsOH were added tothe flask. The reactants were stirred at room temperature for 1 h, and then themixture was heated up gradually to 80 C and refluxed for about 70 h. Thinlayer chromotography (TLC) confirmed the absence of the starting material forthe reactions. The solvent bromoethane was evaporated underreduced pressure after the solution was cooled to room temperature, and firstlyappropriate amount of dichloromethane was added with stirring, secondlyappropriate amount of water was added, separated and the organic layer solutionwas obtained, dried by anhydrous MgSO0.5 mmol of ethoxybenzene, 0.25 mmol of I2, 1.5 mL of acetonitrile solution of nitrosonium tetrafluoroborate (containing 0.1 mmol of nitrosonium tetrafluoroborate in 1.5 mL of the solution) was added to the reaction tube of about 45 mL to sealed reaction tube, The temperature was controlled at 30 ° C and the reaction was carried out under magnetic stirring for 5 hours, followed by cooling the reaction system to room temperature. The reaction mixture was purified by column chromatography to give p-ethoxyiodobenzene with an internal standard yield of 81percent. The structure of the product was determined using 1H-NMR and 13C-NMR, see Figure 3-4.0.5 mmol of ethoxybenzene, 0.25 mmol of I2, 1.5 mL of acetonitrile solution of nitrosonium tetrafluoroborate (containing 0.1 mmol of nitrosonium tetrafluoroborate in 1.5 mL of the solution) was added to the reaction tube of about 45 mL to sealed reaction tube, The temperature was controlled at 30 C and the reaction was carried out under magnetic stirring for 5 hours, followed by cooling the reaction system to room temperature. The reaction mixture was purified by column chromatography to give p-ethoxyiodobenzene with an internal standard yield of 81%. The structure of the product was determined using 1H-NMR and 13C-NMR, see Figure 3-4.

Intermediates of Liquid Crystals suzuki reaction

Molecular Weight:248.06
XLogP3:3.1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:247.96981
Monoisotopic Mass:247.96981
Topological Polar Surface Area:9.2
Heavy Atom Count:10
Complexity:87.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes